Volume 7, Issue 3 (2021)                   Pharm Biomed Res 2021, 7(3): 0-0 | Back to browse issues page

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Yahaya T, Oladele E, Mohammad A, Haruna A, Liman U. Involvement of Epigenetics in the Pathogenesis, Testing and Management of Coronavirus Disease 2019 (COVID-19) Pandomic: A Narrative Review. Pharm Biomed Res. 2021; 7 (3)
URL: http://pbr.mazums.ac.ir/article-1-389-en.html
1- Department of Biology, Federal University Birnin-Kebbi, PMB 1157, Birnin-Kebbi, Nigeria
2- Biology Unit, Distance Learning Institute, University of Lagos, Nigeria
3- Federal University Birnin-Kebbi
4- Department of Biochemistry and Molecular Biology, Federal University Birnin-Kebbi, Nigeria
Abstract:   (146 Views)
Background: There is an intense search for coronavirus disease 19 (COVID19) cure, to stem the spread and burden of the disease worldwide. To this end, some studies revealed that epigenetic modifications play a role in the pathogenesis of some cases of the disease, which can be used as therapeutic targets.
Objectives: This review articulated the role of epigenetics in the pathogenesis and management of COVID-19.
Methods: Relevant articles published between January 2000 and November 2020 were retrieved from reputable academic databases, including PubMed, SpringerLink, Scopus, and Google Scholar.     
Results: Epigenetic modifications in the COVID-19’s pathogen, called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host’s cells may influence susceptibility or resistance to the disease. Notably, abnormal DNA methylation and histone modification involving immune regulatory genes and molecules such as cytokines and interferon-regulated genes may compromise immune function and enhance the host’s susceptibility and disease severity. Hypomethylation of SARS-CoV-2’s receptor called the angiotensin-converting enzyme 2 (ACE2), causing its overexpression can also enhance SARS-CoV-2’s infectivity. Moreover, SARS-CoV-2 can hijack the host’s microRNA (miRNA) using its own miRNA and compromise the immune function, increasing its infectivity. Fortunately, epigenetic changes are reversible, so a therapy that targets the epigenetic changes in the affected may reverse COVID-19.
Conclusion: Modifications in the SARS-CoV-2 or host epigenome promote the pathogenesis and severity of COVID-19. Epigenetic changes are reversible, so healthcare providers are advised to formulate therapeutic procedures that target the causal mechanism (s) in the affected.
     
Type of Study: Original Research | Subject: Genetics

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