Volume 7, Issue 4 (2021)                   Pharm Biomed Res 2021, 7(4): 0-0 | Back to browse issues page

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Ojatula A O. Evaluation of the impact of extraction solvent on bioactive property and in-vitro antioxidant activity in Palma-christi (Anthocleista nobilis G. Don.) root.. Pharm Biomed Res. 2021; 7 (4)
URL: http://pbr.mazums.ac.ir/article-1-398-en.html
Ondo State University of Science and Technology, Okitipupa, Nigeria
Abstract:   (155 Views)
ABSTRACT
Background: Plants entails diverse phytochemicals with different solubility levels, and medicinal efficacy. The purpose of the analysis was to analyze the effects of extraction solvent, methanol, on biomolecule profile and in vitro bioactivity of Anthocleista nobilis root extract.
Materials and Methods: The preliminary phytochemical investigations were performed, using standard analytical procedures. The in vitro antioxidant properties were estimated by: 22-Diphenyl—2-Picryl-Hydrazyl (DPPH), Nitric oxide (NO) Scavenging activity, Ferric Antioxidant Reduction (FRAP), Total Antioxidant Potential (TAC) and Hydrogen Peroxide (H2O2) scavenging activity.
Results: The phytochemical analyses revealed the occurrence of an array of compounds: saponins, reducing sugar, alkaloids, tannins, flavonoids, cardiac glycosides and mucilages, the concentration of which varied between compounds. A considerable presence and quantity of phytochemicals were found in the methanol extract. The impact of the extract on DPPH, NO, FRAP, TAC, H2O2 radicals were dependently and ascendingly concentrated. Solvent extract demonstrated better antioxidant activity, with DPPH and NO showing maximum antioxidant capability in conjunction with IC50 values.
Conclusion: This study present proof that A. nobilis remain a possible source of natural antioxidant, justifying its usage in indigenous medicine.
     
Type of Study: Original Research | Subject: Biotechnology

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