Volume 7, Issue 4 (2021)                   Pharm Biomed Res 2021, 7(4): 0-0 | Back to browse issues page

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Ahangar N, Bakhshi Jouybari H, Davoodi A, Shahani S. Phytochemical Screening and Antinociceptive Activity of the Hydroalcoholic Extract of Potentilla reptans L.. Pharm Biomed Res. 2021; 7 (4)
URL: http://pbr.mazums.ac.ir/article-1-394-en.html
1- Department of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
2- Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:   (138 Views)
Background: Potentilla species traditionally have been used as anti-inflammatory and analgesic agents in Iran and other countries.
Objectives: The aim of this study was to investigate the antinociceptive effect of Potentilla reptans L. which has a wide distribution in the north of Iran.
Methods: The biological activities of the hydroalcoholic extract of P. reptans aerial part have been investigated using the acetic acid-induced writhing, hot plate and rotarod tests in the male mice. In addition, phytochemical profile of the extract has been evaluated.
Results: According to the phytochemical investigation, secondary metabolites such as flavonoids, saponins, triterpenoids and tannins have been detected in the extract. Moreover, the total phenolic and tannin contents of the extract were 251 ± 2.08 and 111.5 ± 1.3 mg Gallic acid equivalents per gram of dried extract, respectively. Also, the total flavonoid content was measured 29.42 ± 3.31 mg quercetin equivalents per gram of dried extract. Oral administration of the extract (100, 300, and 500 mg/kg) dose-dependently reduced the number of writhing responses induced by acetic acid and increased the reaction time in the hot-plate test. The antinociceptive effect of the extract, similar to morphine, was significantly antagonized by naloxone (4 mg/kg; i.p.) in the writhing test. In rotarod test, none of the extract doses used in experiment caused a loss of locomotor activity.
Conclusion: In this study, the hydroalcoholic extract of P. reptans showed a suitable antinociceptive effect in hot plate and writhing tests. It seems that the observed effect could be mediated by opioid receptors.
     
Type of Study: Original Research | Subject: Pharmacognosy

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