Volume 7, Issue 1 (2021)                   Pharm Biomed Res 2021, 7(1): 25-36 | Back to browse issues page

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Ghandadi M. Inhibitory Effects of Salinispora-derived Metabolites Against Multidrug Resistance: An In-silico Study. Pharm Biomed Res. 2021; 7 (1) :25-36
URL: http://pbr.mazums.ac.ir/article-1-364-en.html
Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract:   (507 Views)
Background: Multi drug resistance (MDR) is known to defeat most chemotherapies as one of the main anticancer strategies. The role of overexpression or overactivation of ATP-binding cassette (ABC) transporters, especially P-glycoprotein (P-gp), in the development of chemotherapy has long been demonstrated. Salinispora is a marine actinomycete genus known for the production of novel bioactive metabolites.
Objectives: In this study, the potential of Salinispora derived metabolites as inhibitor of ATP-binding cassette (ABC) transports have been investigated using in-silico approaches.
Methods: Physicochemical, pharmacokinetic and drug likeness of the Salinispora derived metabolites have been analyzed using SwissADME server. This was accompanied by the employment of docking strategy to evaluate anti-MDR potential of the metabolites using P-gp, Breast Cancer Resistance Protein (BCRP) and Multidrug Resistance Protein 1 (MRP-1) as target proteins. 
Results: Nineteen metabolites were found to have demonstrated appropriate physicochemical, pharmacokinetic, and drug-likeness properties and were involved in the docking studies. Based on docking studies, saliniquinones, cyclomarazine, and cyanosporoside A demonstrated ABC transporters inhibitory potential.
Conclusion: Our results suggest that further in vivo and in vitro studies on anti-MDR effects of Salinispora-derived metabolites are warranted.
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Type of Study: Original Research | Subject: Mollecular Modeling

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