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Natural-based drugs are the important bioactive substances that have been used for prevention and treatment of diseases. Natural products should be prepared in commercial scale from relevant medicinal plants. Hence, large amounts of the plants have been needed for extraction and isolation of compounds of natural origin. Plant cells technology is the best strategy for the production of the plant-derived drugs, which have difficulty in high scale preparation. This study was conducted for types, frequencies and efficacies of production methods for natural-based drugs in plant cell technology as alternative method to whole herb. Pharmaceutical and biomedical databases including PubMed/Medline, Scopus, Web of Science, Embase, ProQuest and Google Scholar were searched in this study. Moreover, keywords words were ''secondary metabolite production'', ''pharmaceutical natural compounds'', ''high scale production'', ''cell suspension'', ''immobilized plant cell'', “hairy root”, ''elicitor'', ''substrate'', ''plant cell'', ''callus'', ''medicinal plants'', ''isolation and purification''. The correlations have been investigated by random effect model in an Excel program. Findings of this meta-analysis study showed all production methods had high efficacies and percentages of high scale production from 90 to 100%, which were comparable with conventional direct extractions. In addition to, median efficacy values for cell suspension, callus, hairy root and immobilized plant cell methods in production of selected drugs (atropine, paclitaxel, vincristine, camptothecin and colchicine) with 1124, 257, 797 and 969 events were 92.49 (CI_95%: 89.78-95.86), 91.98 (CI_95%: 89.13-95.25), 95.69 (CI_95%: 92.84-98.68) and 93.86% (CI_95%: 91.12-96.35), respectively. The plant cell technology for production of secondary metabolites has various advantages including high accuracy, repeatability and productivity, that is a best strategy for production of natural-based drugs.

Keywords: Plant cell, hairy root, callus, immobilized cell, meta-analysis

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