Volume 2, Issue 3 (2016)                   Pharm Biomed Res 2016, 2(3): 25-30 | Back to browse issues page

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Mousavi S A, Ghasemi M, Mousavi S J, Mousavi Darka S S, Bagheri V. Comparison of leeching and heparin therapy in management of acute venous congestion of limbs in rat . Pharm Biomed Res. 2016; 2 (3) :25-30
URL: http://pbr.mazums.ac.ir/article-1-128-en.html
1- Department of Pediatric Surgery, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2- Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3- Community Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4- General physician, Mazandaran University of Medical Sciences, Sari, Iran
5- Department of General Surgery, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:   (4941 Views)

Acute venous congestion leads to blood stasis in the tissue and impaired blood perfusion. Using medicinal leech is an old method for reducing tissue congestion. There are numerous factors in leech saliva and hirudin that have important roles in the leeching beneficial effect. In this study, an animal study was performed to compare leech therapy with heparin therapy in the treatment of acute venous congestion. Thirty male rats were divided into three groups. In the first group, an acute venous congestion was induced at the thigh. Decongestion was performed through the touch of hirudo medicinalis leech. In the second group, heparin sodium was injected, after tourniquet removal. Eventually, no treatment or procedure was performed in the third group after opening of tourniquet. Histopathological and biochemical analysis were performed in these rat. Edema size in heparin therapy and control groups was significantly greater than leech therapy group. Creatine phosphokinase blood level in leech therapy group was significantly lower than the control group, but this difference was unobserved between heparin therapy and control. In contrast, the level of lactate dehydrogenase and aldolase greatly increased in the control group, which received no intervention. Also in histopathological assessment, the level of tissue damage in both heparin and leech therapy groups showed a significant decrease as compared to the control group. Leech therapy can probably be more effective in the reducing of cellular damage caused by acute tissue congestion as compare to heparin therapy.

Keywords: Leech, heparin, vein, congestion
Full-Text [PDF 376 kb]   (2561 Downloads)    
Type of Study: Original Research | Subject: Clinical Pharmacy

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