Volume 1, Number 4 (December 2015)                   mazums-pbr 2015, 1(4): 40-47 | Back to browse issues page



DOI: 10.18869/acadpub.pbr.1.4.40

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noroozpour Dailami K, Azadbakht M, Lashgari M, Rashidi Z. Prevention of selenite-induced cataractogenesis by hydroalchoholic extract of Echium amoenum: An experimental evaluation of the Iranian traditional eye medication. mazums-pbr. 2015; 1 (4) :40-47
URL: http://pbr.mazums.ac.ir/article-1-79-en.html

Department of Pharmacognosy, Faculty of Pharmacy, Health of Plant and Livestock Products Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:   (1299 Views)

Echium amoenum is an Iranian indigenous medicinal plant. In this research the effect of hydroalchoholic extract of this plant on sodium-selenite induced cataract formation was evaluated. Fifty five white rat pups were selected and divided into six groups. In first group (control 1) no elements injected. Second group (control 2) was received normal saline on 11-18 postpartum. Hydroalchoholic extract of Echium amoenum flower (400 mg/kg/day) intraperitonealy was injected into third group. Rats in group 4th received sodium selenite (30 nmol/kg) on day 13 postpartum. In group 5th, the extract was injected 2 days before selenite injection (once a day for two days). And in last group one day before selenite injection, the rats received a single dose of the extract. Cataract development was measured by slit- lamp. Lens opacification was analyzed in each group on day 7 after selenite administration. All lens in control and 3th groups were clear. However, it was found different type of cataract grades formation in selenite group (2.2 ± 0.83). Cataract grades were 0.4 ± 0.5 and 0.6 ± 0.5 in groups 5th and 6th respectively. Echium amoenum extract significantly was shown a protective effect on selenite-induced cataract in rat. This effect is probably associated with antioxidant activity of this medicinal plant.

Full-Text [PDF 349 kb]   (674 Downloads)    
Type of Study: Research | Subject: Clinical Pharmacy

Add your comments about this article : Your username or email:
Write the security code in the box

© 2015 All Rights Reserved | Pharmaceutical and Biomedical Research

Designed & Developed by : Yektaweb