Volume 12, Issue 1 (2026)
Pharm Biomed Res 2026, 12(1): 49-60 |
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Philip A G, Salihu A M, Ajoke F L, Yanda S E, Timothy A U, Daniel J et al . Characterization and Antimicrobial Activity of Biosynthesized Iron (III) Oxide Nanoparticles Stabilized by Luffa cylindrica Extract. Pharm Biomed Res 2026; 12 (1) :49-60
URL: http://pbr.mazums.ac.ir/article-1-707-en.html
URL: http://pbr.mazums.ac.ir/article-1-707-en.html
Azaki Gideon Philip *1 
, Adamu Makanta Salihu2 , Fadipe Labake Ajoke1 , Shaba Elijah Yanda3 , Agbai Uche Timothy4 , James Daniel5 , Suleiman Rahmat6
, Adamu Makanta Salihu2 , Fadipe Labake Ajoke1 , Shaba Elijah Yanda3 , Agbai Uche Timothy4 , James Daniel5 , Suleiman Rahmat6
1- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria.
2- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria. & Department of Chemistry and Biochemistry, Sharda School of Basic Sciences and Research (SSBSR), Sharda University, Greater Noida, India.
3- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria. & Nanotechnology Research Group, Africa Centre of Excellence for Mycotoxin and Food Safety, Federal University of Technology, Minna, Nigeria.
4- Department of Chemistry and Biochemistry, College of Engineering and Physical Sciences, University of New Hampshire, Durham, United States.
5- Wuhan Institute of Virology, University of Chinese Academy of Sciences, Beijing, China.
6- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria. & Department of Chemistry, Niger State College of Education, Minna, Nigeria.
2- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria. & Department of Chemistry and Biochemistry, Sharda School of Basic Sciences and Research (SSBSR), Sharda University, Greater Noida, India.
3- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria. & Nanotechnology Research Group, Africa Centre of Excellence for Mycotoxin and Food Safety, Federal University of Technology, Minna, Nigeria.
4- Department of Chemistry and Biochemistry, College of Engineering and Physical Sciences, University of New Hampshire, Durham, United States.
5- Wuhan Institute of Virology, University of Chinese Academy of Sciences, Beijing, China.
6- Department of Chemistry, School of Physical Sciences, Federal University of Technology, Minna, Nigeria. & Department of Chemistry, Niger State College of Education, Minna, Nigeria.
Abstract: (109 Views)
Background: The search for environmentally friendly nanomaterials with strong antimicrobial activity has generated growing interest in using plants to produce nanoparticles.
Objectives: This study aimed to biosynthesize and characterize iron (III) oxide (Fe2O3) nanoparticles stabilized by Luffa cylindrica extract and assess their antimicrobial properties.
Methods: The biosynthesized Fe2O3 nanoparticles were characterized using ultraviolet–visible (UV–Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy to elucidate their optical, structural, morphological, and elemental properties.
Results: The formation of Fe2O3 nanoparticles was confirmed by standard absorbance at 370 nm and functional groups attributed to the capping and stabilization observed via FTIR. XRD patterns showed a crystalline rhombohedral phase, and SEM images indicated that the nanoparticles were uniformly dispersed with diameters of 20-50 nm. Nanoparticle efficacy was tested using the agar well diffusion method against a panel of gram-positive and gram-negative bacterial strains and fungal pathogens. The results revealed substantial dose-dependent antimicrobial activity, with greater inhibitory activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, indicating potential broad-spectrum antimicrobial activity.
Conclusion: This study highlights the potential of L. cylindrica-mediated Fe2O3 nanoparticles as sustainable and effective antimicrobial agents with potential application in the biomedical, pharmaceutical, and environmental fields.
Objectives: This study aimed to biosynthesize and characterize iron (III) oxide (Fe2O3) nanoparticles stabilized by Luffa cylindrica extract and assess their antimicrobial properties.
Methods: The biosynthesized Fe2O3 nanoparticles were characterized using ultraviolet–visible (UV–Vis) spectroscopy, Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy to elucidate their optical, structural, morphological, and elemental properties.
Results: The formation of Fe2O3 nanoparticles was confirmed by standard absorbance at 370 nm and functional groups attributed to the capping and stabilization observed via FTIR. XRD patterns showed a crystalline rhombohedral phase, and SEM images indicated that the nanoparticles were uniformly dispersed with diameters of 20-50 nm. Nanoparticle efficacy was tested using the agar well diffusion method against a panel of gram-positive and gram-negative bacterial strains and fungal pathogens. The results revealed substantial dose-dependent antimicrobial activity, with greater inhibitory activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, indicating potential broad-spectrum antimicrobial activity.
Conclusion: This study highlights the potential of L. cylindrica-mediated Fe2O3 nanoparticles as sustainable and effective antimicrobial agents with potential application in the biomedical, pharmaceutical, and environmental fields.
Type of Study: Original Research |
Subject:
Nanotechnology
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