Volume 12, Issue 1 (2026)
Pharm Biomed Res 2026, 12(1): 0-0 |
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Shokrzadeh M, Modanloo M, Fasihbeiki M, Zamani E, Alinia M, Shaki F. Atorvastatin Mitigates Cisplatin-Induced Genotoxicity and Oxidative Stress in Human Lymphocytes: Insights from the Micronucleus Assay. Pharm Biomed Res 2026; 12 (1)
URL: http://pbr.mazums.ac.ir/article-1-677-en.html
URL: http://pbr.mazums.ac.ir/article-1-677-en.html
Mohammad Shokrzadeh1 
, Mona Modanloo1 , Mina Fasihbeiki2 , Ehsan Zamani3 , Mona Alinia3 , Fatemeh Shaki *1
, Mona Modanloo1 , Mina Fasihbeiki2 , Ehsan Zamani3 , Mona Alinia3 , Fatemeh Shaki *1
1- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2- Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
3- Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
2- Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
3- Department of Pharmacology and Toxicology, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
Abstract: (51 Views)
Cisplatin, a member of the alkylating agent class within the antineoplastic agent family, is primarily indicated for the treatment of bladder, ovarian, and testicular cancers. Prolonged administration of cisplatin can result in genotoxicity attributable to the probable involvement of oxidative stress as an underlying molecular mechanism. This study investigates the intriguing potential of atorvastatin in mitigating the effects of cisplatin. Peripheral lymphocytes in cell culture were divided into 4 groups: control, cisplatin (12 μM), atorvastatin combined cisplatin (50,100,1000 μM), and atorvastatin(1000 μM). Following collection and slide preparation, the frequency of micronuclei (MN) was examined as an indicator of genotoxicity; additionally, levels of glutathione (GSH) and lipid peroxidation (LPO) were measured to assess oxidative stress parameters. The results revealed a rise in micronuclei and LPO, along with a decrease in GSH levels in lymphocytes treated with cisplatin compared to the control group. However, when atorvastatin was introduced alongside cisplatin, it significantly ameliorated the increase in Mn, LPO, and ROS concurrently restoring GSH levels in these lymphocytes. The findings indicated that cisplatin triggers genotoxicity in cultured human lymphocytes, with oxidative stress playing a crucial role in this process. Moreover, it can be concluded that atorvastatin effectively protects against genotoxicity by virtue of its potent antioxidant properties, sparking further interest in its potential use in mitigating the effects of cisplatin.
Type of Study: Original Research |
Subject:
Toxicology
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