Volume 11, Issue 2 (2025)
Pharm Biomed Res 2025, 11(2): 159-172 |
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Sabahsan E, Yildiz E, Karatas Y. Synthesis of Rhodanine-N-acetic Acid Metal Complexes: Bioactivity of Its Iron Complex as Potential Prodrug Approach for Alzheimer’s Disease. Pharm Biomed Res 2025; 11 (2) :159-172
URL: http://pbr.mazums.ac.ir/article-1-671-en.html
URL: http://pbr.mazums.ac.ir/article-1-671-en.html
1- Department of Chemistry, Faculty of Arts and Science, Cukurova University, Adana, Turkey.
2- Department of Medical Pharmacology, Faculty of Medicine, Cukurova University, Adana, Turkey.
2- Department of Medical Pharmacology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Abstract: (83 Views)
Background: Heavy metal accumulation has been shown to improve memory impairment, which is the most visible symptom of Alzheimer’s disease (AD).
Objectives: This study was conducted to select and synthesize rhodanine-N-acetic acid (ROD) ligand as an azosulpha drug, as well as its metal complexes containing Fe(III), Mn(III), and Cu(II), to evaluate the iron complex’s bioactivity in Swiss Albino rats.
Methods: A new series of metal complexes were synthesized and characterized using elemental analysis, magnetic susceptibility, spectroscopic, and analytical methods, including Fourier-transform infrared spectroscopy (FT-IR), inductively coupled plasma (ICP), and thermogravimetric analysis (TG). The effects of heavy metal accumulation of the characterized iron complex on rats were investigated through in vivo studies.
Results: The results indicated that as the iron load in the liver and spleen tissues increased, the iron-binding capacity of the ROD ligand also significantly increased.
Conclusion: These findings suggest that the activity of ROD metal complexes should be investigated further as a potential prodrug for AD.
Objectives: This study was conducted to select and synthesize rhodanine-N-acetic acid (ROD) ligand as an azosulpha drug, as well as its metal complexes containing Fe(III), Mn(III), and Cu(II), to evaluate the iron complex’s bioactivity in Swiss Albino rats.
Methods: A new series of metal complexes were synthesized and characterized using elemental analysis, magnetic susceptibility, spectroscopic, and analytical methods, including Fourier-transform infrared spectroscopy (FT-IR), inductively coupled plasma (ICP), and thermogravimetric analysis (TG). The effects of heavy metal accumulation of the characterized iron complex on rats were investigated through in vivo studies.
Results: The results indicated that as the iron load in the liver and spleen tissues increased, the iron-binding capacity of the ROD ligand also significantly increased.
Conclusion: These findings suggest that the activity of ROD metal complexes should be investigated further as a potential prodrug for AD.
Type of Study: Original Research |
Subject:
Medical Chemistry
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