Volume 11, Issue 1 (2025)
Pharm Biomed Res 2025, 11(1): 49-60 |
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Dawoud A D H, Abdalbagi M, Shayoub M E H. Formulation and Assessment of Drug Release and Stability of New Antipsoriatic Emulgel. Pharm Biomed Res 2025; 11 (1) :49-60
URL: http://pbr.mazums.ac.ir/article-1-664-en.html
URL: http://pbr.mazums.ac.ir/article-1-664-en.html
1- Department of Drug Formulation, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartum, Sudan. & Department of Pharmaceutics, Faculty of Pharmacy, National Ribat University, Khartum, Sudan.
2- Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartum, Sudan.
3- Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
2- Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartum, Sudan.
3- Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Khartoum, Sudan.
Abstract: (300 Views)
Background: The objective of the present study was to formulate a new antipsoriatic emulgel from Aloe sinkatana extract, evaluate the formulations, and select an optimized formulation through in vitro drug release and drug content studies. A. sinkatana plant is a potent antipsoriatic agent traditionally used to treat psoriasis. The development of a dermal drug delivery system can overcome these side effects.
Methods: A 23 factorial design was selected to formulate A. sinkatana emulgel. The prepared emulgel was evaluated for general appearance, pH, viscosity, drug content, in vitro drug release, kinetics, and stability.
Results: Optimized formulation F3 showed the highest drug content and best in vitro drug release. The stability study for the optimized formulation was carried out at 25°C/60% relative humidity (RH), 30°C/65% RH, and 40°C/75% RH for 3 months, and the emulgel was found to be stable concerning the physical appearance, PH, phase separation, drug content, and microbial growth.
Conclusion: The study revolved around the formulation of emulgel containing A. sinkatana extract for dermal delivery of the drug. It was finally concluded that the emulgel formula F3 was the most promising topical herbal emulgel.
Methods: A 23 factorial design was selected to formulate A. sinkatana emulgel. The prepared emulgel was evaluated for general appearance, pH, viscosity, drug content, in vitro drug release, kinetics, and stability.
Results: Optimized formulation F3 showed the highest drug content and best in vitro drug release. The stability study for the optimized formulation was carried out at 25°C/60% relative humidity (RH), 30°C/65% RH, and 40°C/75% RH for 3 months, and the emulgel was found to be stable concerning the physical appearance, PH, phase separation, drug content, and microbial growth.
Conclusion: The study revolved around the formulation of emulgel containing A. sinkatana extract for dermal delivery of the drug. It was finally concluded that the emulgel formula F3 was the most promising topical herbal emulgel.
Type of Study: Original Research |
Subject:
Pharmaceutics
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