Volume 11, Issue 2 (2025)
Pharm Biomed Res 2025, 11(2): 139-146 |
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Fagbohun B O, Ogar O E, Messiah A I, Adewuyi H A, Adio W S, Oluwatoyin A H, et al . Antihypertensive Potential of Euphorbia hirta and Leptadenia hastata in Adrenaline-induced Wistar Rats. Pharm Biomed Res 2025; 11 (2) :139-146
URL: http://pbr.mazums.ac.ir/article-1-659-en.html
URL: http://pbr.mazums.ac.ir/article-1-659-en.html
Bushirat Oyenike Fagbohun1 
, Ochonung Emmanuel Ogar2 , Atapia Innocent Messiah2 , Hassan Abdulsalam Adewuyi *3 , Waheed Sakariyau Adio4 , Adebimpe Hameedah Oluwatoyin5 , Chizoba Victory Obunadike6 , Adeleye Adegboyega Edema7 , Samad Hussein3 , Usman Abiola Mohammed8 , Tolulope Olukayode Jaiyeola9
, Ochonung Emmanuel Ogar2 , Atapia Innocent Messiah2 , Hassan Abdulsalam Adewuyi *3 , Waheed Sakariyau Adio4 , Adebimpe Hameedah Oluwatoyin5 , Chizoba Victory Obunadike6 , Adeleye Adegboyega Edema7 , Samad Hussein3 , Usman Abiola Mohammed8 , Tolulope Olukayode Jaiyeola9
1- Department of Pharmacy Technician, Ogun State College of Health Science and Technology, Ogun, Nigeria.
2- Department of Chemical Engineering, University of Benin, Benin City, Nigeria.
3- Department of Biochemistry, Federal University of Technology, Minna, Nigeria.
4- Department of Chemistry and Biochemistry, College of Science, Old Dominion University, Norfolk, United States.
5- Department of Chemistry and Biochemistry, College of Health and Natural Sciences-Keplinger Hall, The University of Tulsa, Oklahoma, United States.
6- Department of Industrial Chemistry, College of Pure and Applied Chemistry, Osun State University Osogbo, Osun, Nigeria.
7- Department of Biochemistry, University of Ibadan, Oyo State Nigeria.
8- Department of Biological Sciences, AhmanPategi University, Pategi, Nigeria.
9- Department of Biological Sciences, Crawford University, Ketu Adieowe, Nigeria.
2- Department of Chemical Engineering, University of Benin, Benin City, Nigeria.
3- Department of Biochemistry, Federal University of Technology, Minna, Nigeria.
4- Department of Chemistry and Biochemistry, College of Science, Old Dominion University, Norfolk, United States.
5- Department of Chemistry and Biochemistry, College of Health and Natural Sciences-Keplinger Hall, The University of Tulsa, Oklahoma, United States.
6- Department of Industrial Chemistry, College of Pure and Applied Chemistry, Osun State University Osogbo, Osun, Nigeria.
7- Department of Biochemistry, University of Ibadan, Oyo State Nigeria.
8- Department of Biological Sciences, AhmanPategi University, Pategi, Nigeria.
9- Department of Biological Sciences, Crawford University, Ketu Adieowe, Nigeria.
Abstract: (76 Views)
Background: Hypertension is a major public health concern worldwide, contributing to cardiovascular morbidity and mortality. The use of plant-based therapies, such as Euphorbia hirta and Leptadenia hastata, has gained attention for their potential antioxidant, anti-hyperlipidemic, and organ-protective effects.
Objectives: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats
Methods: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters.
Results: Antioxidant activity: Increased levels of superoxide dismutase, catalase, and glutathione peroxidase. Lipid profiles: Reduced levels of total cholesterol, triglycerides, and LDL cholesterol. Liver function tests (LFTs): Decreased levels of alanine transaminase and aspartate transaminase. Hematological parameters: Improved red blood cell count, hemoglobin, and packed cell volume (PCV).
Conclusion: This preclinical investigation provides compelling evidence for the antihypertensive potential of E. hirta and L. hastata leaf extracts, validating their traditional use. These findings underscore the promise of these natural products as adjunctive therapeutics for hypertension management, warranting further clinical investigation.
Objectives: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats
Methods: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters.
Results: Antioxidant activity: Increased levels of superoxide dismutase, catalase, and glutathione peroxidase. Lipid profiles: Reduced levels of total cholesterol, triglycerides, and LDL cholesterol. Liver function tests (LFTs): Decreased levels of alanine transaminase and aspartate transaminase. Hematological parameters: Improved red blood cell count, hemoglobin, and packed cell volume (PCV).
Conclusion: This preclinical investigation provides compelling evidence for the antihypertensive potential of E. hirta and L. hastata leaf extracts, validating their traditional use. These findings underscore the promise of these natural products as adjunctive therapeutics for hypertension management, warranting further clinical investigation.
Keywords: Antihypertensive, Euphorbia hirta, Leptadenia hastata, traditional medicine, Cardiovascular disorders, Phytotherapy, Cardiovascular
Type of Study: Original Research |
Subject:
Ehtnopharmacology
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