Volume 11, Issue 2 (2025)
Pharm Biomed Res 2025, 11(2): 95-104 |
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Olapeju Bolanl I, Erharuyi O, Akhigbemen A M, Ugiagbe A I, Ekugum E, Nwusulor S O, et al . Valsartan and Amlodipine Improved Haematological and Biochemical Indices of Vildagliptin-treated Streptozotocin-induced Diabetic Rats. Pharm Biomed Res 2025; 11 (2) :95-104
URL: http://pbr.mazums.ac.ir/article-1-651-en.html
URL: http://pbr.mazums.ac.ir/article-1-651-en.html
Israel Olapeju Bolanl *1 
, Osayemwenre Erharuyi2 , Abigail M. Akhigbemen3 , Amenaghawon Imuetinyan Ugiagbe3 , Edobor Ekugum4 , Samuel O. Nwusulor1 , Keziah E. Adudu1 , Abiodun Falodun2
, Osayemwenre Erharuyi2 , Abigail M. Akhigbemen3 , Amenaghawon Imuetinyan Ugiagbe3 , Edobor Ekugum4 , Samuel O. Nwusulor1 , Keziah E. Adudu1 , Abiodun Falodun2
1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
2- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
3- Department of Pharmacy, University of Benin Teaching Hospital, University of Benin, Benin City, Nigeria.
4- Department of Pharmaceutical Technology, Edo State Polytechnic Usen, Usen, Nigeria.
2- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.
3- Department of Pharmacy, University of Benin Teaching Hospital, University of Benin, Benin City, Nigeria.
4- Department of Pharmaceutical Technology, Edo State Polytechnic Usen, Usen, Nigeria.
Abstract: (80 Views)
Background: Diabetes mellitus (DM) and hypertension often coexist in sufferers, which exacerbates the complications of DM. Also, the impacts of antihypertensive medications on the treatment outcomes of DM are not fully understood.
Objectives: Our objective was to evaluate the effect of valsartan and amlodipine on the hematological and biochemical differentials of vildagliptin-treated streptozotocin-induced diabetic rats.
Methods: DM was induced in male Wistar rats by a single intraperitoneal dose of streptozotocin (40 mg/kg body weight). The animals were grouped as non-diabetic rats (control), untreated diabetic rats, and diabetic rats treated with 5 mg/kg vildagliptin only, 5 mg/kg plus 30 mg/kg of vildagliptin and valsartan, respectively, and 5 mg/kg plus 2.5 mg/kg of vildagliptin and amlodipine, respectively. Drugs were administered orally, and rats were treated daily for three weeks. Then, blood samples were collected for hematological and biochemical analyses.
Results: The addition of amlodipine and valsartan as adjuncts to vildagliptin appeared to alter the evaluated differentials compared to vildagliptin treatment alone. Furthermore, the assessment of renal and liver functions, as well as the lipid profile, showed that treatment with valsartan as an adjunct improved the outcomes.
Conclusion: Our findings therefore suggest that amlodipine and valsartan brought about significant alterations in the differentials of diabetic rats treated with vildagliptin.
Objectives: Our objective was to evaluate the effect of valsartan and amlodipine on the hematological and biochemical differentials of vildagliptin-treated streptozotocin-induced diabetic rats.
Methods: DM was induced in male Wistar rats by a single intraperitoneal dose of streptozotocin (40 mg/kg body weight). The animals were grouped as non-diabetic rats (control), untreated diabetic rats, and diabetic rats treated with 5 mg/kg vildagliptin only, 5 mg/kg plus 30 mg/kg of vildagliptin and valsartan, respectively, and 5 mg/kg plus 2.5 mg/kg of vildagliptin and amlodipine, respectively. Drugs were administered orally, and rats were treated daily for three weeks. Then, blood samples were collected for hematological and biochemical analyses.
Results: The addition of amlodipine and valsartan as adjuncts to vildagliptin appeared to alter the evaluated differentials compared to vildagliptin treatment alone. Furthermore, the assessment of renal and liver functions, as well as the lipid profile, showed that treatment with valsartan as an adjunct improved the outcomes.
Conclusion: Our findings therefore suggest that amlodipine and valsartan brought about significant alterations in the differentials of diabetic rats treated with vildagliptin.
Type of Study: Original Research |
Subject:
Pharmacology
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