Volume 11, Issue 1 (2025)
Pharm Biomed Res 2025, 11(1): 69-74 |
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Farzaneh A H, Khosravi N. Ergotamine/Caffeine Overdose in a Female Suffering From Migraine Headache: A Case Report. Pharm Biomed Res 2025; 11 (1) :69-74
URL: http://pbr.mazums.ac.ir/article-1-618-en.html
URL: http://pbr.mazums.ac.ir/article-1-618-en.html
1- Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
2- oxicology and Forensic Medicine Division, Mazandaran Registry Center for Opioids Poisoning, Mazandaran University of Medical Sciences, Sari, Iran. & Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran. & Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
2- oxicology and Forensic Medicine Division, Mazandaran Registry Center for Opioids Poisoning, Mazandaran University of Medical Sciences, Sari, Iran. & Antimicrobial Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran. & Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract: (115 Views)
Background: Ergotamine is a very common antimigraine and is widely used in the management of headaches such as cluster and acute migraines. However, Ergotamine poisoning is an infrequent condition, and there are very few cases reported. Tachycardia and arterial spasms occasionally occur because of accidental overdosing or interactions. There are no specific antidotes, and none of the current treatments have proven efficacy.
Case Report: Here, we describe a young female who intentionally consumed approximately 20 mg of ergotamine and experienced vomiting, vasospasm, and tachycardia. Fortunately, her symptoms improved with the administration of conservation therapy, enoxaparin, nifedipine, and methylprednisolone.
Conclusion: Clinicians should be aware of the potential risk of vasoconstriction associated with ergotamine/caffeine toxicity and closely monitor patients for these side effects.
Case Report: Here, we describe a young female who intentionally consumed approximately 20 mg of ergotamine and experienced vomiting, vasospasm, and tachycardia. Fortunately, her symptoms improved with the administration of conservation therapy, enoxaparin, nifedipine, and methylprednisolone.
Conclusion: Clinicians should be aware of the potential risk of vasoconstriction associated with ergotamine/caffeine toxicity and closely monitor patients for these side effects.
Type of Study: case report |
Subject:
Toxicology
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