Volume 7, Issue 3 (2021)                   Pharm Biomed Res 2021, 7(3): 0-0 | Back to browse issues page

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Mohammadzadeh H, Mohammadi H, Tavakoli M, Sadeghi S. Sudden death due to the Acetone toxicity. Pharm Biomed Res. 2021; 7 (3)
URL: http://pbr.mazums.ac.ir/article-1-348-en.html
1- Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran
2- Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
3- Legal Medicine Center of North Khorasan Province, Bojnurd, Iran
Abstract:   (2671 Views)
Propanone is a volatile liquid that can be absorbed by ingestion, inhalation, dermal and is distributed throughout the body. In this study, a fatal case involving acetone poisoning, who was worked in the Red Crescent Medical Center is presented. The deceased was found four hours after death. He was a 25-year-old male nurse and not married. There are the history of smoking since four years ago, diarrhea and nausea on the day before death and without a history of diabetic and alcoholism and no other definite causes. A postmortem examination was performed to define the cause of death. Postmortem quantitative toxicological analysis with GC-FID showed acetone in the vitreous (35 mg/dl), blood (28 mg/dl) and urine (77 mg/dl) samples. Also, in postmortem pathological analysis, highly microvascular changes and diffuse necrosis of hepatocytes were reported. Other pathological changes in brain and lungs were observed. There is no definite other medical cause of death. The cause of death was determined to be an acute acetone intoxication. Therefore, contrary to public opinion, acetone is a toxic and dangerous substance, as well as it is necessary to improve implement public safeguards on acetone usage, handling, and disposal. Organ toxicity due to acetone can be a major cause of death. Other alcohol-related poisoning deaths, such as acetone and other metabolites should be considered.
     
Type of Study: case report | Subject: Toxicology

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