Volume 6, Issue 1 (2020)                   Pharm Biomed Res 2020, 6(1): 53-60 | Back to browse issues page


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Hosseini S A, Ahmadipour A, Soltani M, Mehdipour M, Mandegary A, Karami-Mohajeri S. Malathion-increased Hepatotoxicity in Diabetic Rats. Pharm Biomed Res. 2020; 6 (1) :53-60
URL: http://pbr.mazums.ac.ir/article-1-280-en.html
1- Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
2- Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.; Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Abstract:   (163 Views)
Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus. 
Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats. 
Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined. 
Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe.
Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system. 
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Type of Study: Original Research | Subject: Toxicology

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