Volume 6, Issue 2 (2020)
Pharm Biomed Res 2020, 6(2): 105-114 |
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Gholizadeh Shirdarreh G, Eslami G, Soleimani A, Salehifar E. Evaluation of Aminoglycosides Consumption in Open Heart Surgery Based on the Defined Daily Dose Index. Pharm Biomed Res 2020; 6 (2) :105-114
URL: http://pbr.mazums.ac.ir/article-1-270-en.html
URL: http://pbr.mazums.ac.ir/article-1-270-en.html
1- Department of Clinical Pharmacy, Cardiovascular Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Anaesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
3- Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
2- Department of Anaesthesiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
3- Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract: (2029 Views)
Background: Resistance to antibiotics, including aminoglycosides (AMG) is one of the problems associated with inappropriate administration of broad-spectrum antibiotics. Objectives: This study aimed to assess the clinical features of aminoglycosides consumption based on the Defined Daily Dose (DDD) index in open heart surgery.
Methods: This study was done on 268 patients who underwent heart surgery during 2015 and 2016. Clinical and demographic characteristics, laboratory data, and aminoglycoside-related data such as dose and the total duration of administration were collected through a questionnaire designed by the authors. The patients’ DDD/100 bed-days were calculated, too.
Results: Out of 268 patients, 170 patients (63.4%) were male. The Mean±SD age of the patients was 60.65±10.71 years and the Mean±SD duration of hospitalization was 12.19±7.02 days. Ischemic heart disease was the most prevalent cause of hospitalization. The Mean duration of receiving aminoglycosides was 3.61 days. In 134 patients (50%), creatinine clearance was less than 60 mL/min during aminoglycosides administration. In 25 patients (9.32%), a 50% increase in serum creatinine during receiving aminoglycosides was observed. Creatinine clearance had not been calculated for any patient.
Conclusion: In this study, monitoring the side effects of aminoglycosides and the serum concentration was not routinely performed. Dose adjustment of aminoglycosides based on renal function test was not considered in a large number of patients and as a result, the dose was inappropriate in many patients. Therefore, it is recommended that the guidelines of drug usage were followed and the patients were monitored more closely for side effects.
Methods: This study was done on 268 patients who underwent heart surgery during 2015 and 2016. Clinical and demographic characteristics, laboratory data, and aminoglycoside-related data such as dose and the total duration of administration were collected through a questionnaire designed by the authors. The patients’ DDD/100 bed-days were calculated, too.
Results: Out of 268 patients, 170 patients (63.4%) were male. The Mean±SD age of the patients was 60.65±10.71 years and the Mean±SD duration of hospitalization was 12.19±7.02 days. Ischemic heart disease was the most prevalent cause of hospitalization. The Mean duration of receiving aminoglycosides was 3.61 days. In 134 patients (50%), creatinine clearance was less than 60 mL/min during aminoglycosides administration. In 25 patients (9.32%), a 50% increase in serum creatinine during receiving aminoglycosides was observed. Creatinine clearance had not been calculated for any patient.
Conclusion: In this study, monitoring the side effects of aminoglycosides and the serum concentration was not routinely performed. Dose adjustment of aminoglycosides based on renal function test was not considered in a large number of patients and as a result, the dose was inappropriate in many patients. Therefore, it is recommended that the guidelines of drug usage were followed and the patients were monitored more closely for side effects.
Keywords: Intensive Care Units (ICU), Rational use, Cardiac surgery, Microbial resistance, Prophylactic antibiotic, Aminoglycosides, Defined Daily Dose (DDD)
Type of Study: Original Research |
Subject:
Clinical Pharmacy
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