Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice

Kalantari, Heibatullah; Alijani, Anis; Kheradmand, Parvin; Goodarzian, Maedeh; Zeidooni, Leila

doi:10.18502/pbr.v5i3.2112

Volume 5, Issue 3 (2019) Pharm Biomed Res 2019, 5(3): 8-14 | Back to browse issues page

‎ 10.18502/pbr.v5i3.2112

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Kalantari H, Alijani A, Kheradmand P, Goodarzian M, Zeidooni L. Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice. Pharm Biomed Res 2019; 5 (3) :8-14
URL: http://pbr.mazums.ac.ir/article-1-251-en.html

Hydroalcoholic Extract of Iranian Caper Leaves Protects Hepatic Toxicity by Suppressing Oxidative Stress in Mice

Heibatullah Kalantari¹

, Anis Alijani²

, Parvin Kheradmand³

, Maedeh Goodarzian³

, Leila Zeidooni ^*

⁴

1- Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2- Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3- Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract: (2994 Views)

Capparis spinosa L. (caper) is an aromatic plant, commonly used in the Mediterranean diet, possessing numerous antioxidant compounds, such as phenols, rutin, tocopherols, carotenoids, and vitamin C in its leaves. Thus, the present study investigated the effects of Iranian caper leaves extract on oxidative stress caused by CCl₄ in the mice’s liver.This study was conducted on 42 male mice in seven groups. The control group, the sham group, the CCl₄ group, the Iranian caper leaves extract 100, 200, and 400 mg/kg + CCl₄groups. Then, Biochemicals, oxidative stress, and hepatic histopathology parameters were evaluated. The co-administration of Iranian caper leaves extract, and CCl₄ significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, and reactive oxygen species, malondialdehyde (P<0.001) and significantly increased the levels of glutathione and catalase in comparison with the group treated with CCl₄ alone (P<0.01). Furthermore, Iranian caper leaves extract improved histopathological changes such as the the inflammation and necrosis of hepatocytes. Iranian caper leaves extract has protective effects on hepatotoxicity induced by CCl_4, mainly through suppressing oxidative stress.

Keywords: Iranian caper, Carbon tetrachloride, Oxidative stress, Liver, Mice

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Type of Study: Original Research | Subject: Toxicology

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