Volume 5, Issue 2 (2019)                   mazums-pbr 2019, 5(2): 10-16 | Back to browse issues page

XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Patel S, Dubey N, Gajbhiye A, Patil S. Floating microspheres encapsulating Carvedilol for effective management of hypertension. mazums-pbr. 2019; 5 (2) :10-16
URL: http://pbr.mazums.ac.ir/article-1-212-en.html
SVN Institute of Pharmaceutical Sciences, Swami Vivekanand University, Sagar (M.P)
Abstract:   (145 Views)
The purpose of this research was to prepare a floating drug delivery system of carvedilol. In the present study, preparation of carvedilol floating microspheres, evaluation of Floating Drug Delivery System (FDDS) SEM, in vitro, stability, and in vivo profile were investigated. Floating microspheres were prepared by solvent evaporation (Oil-in-water emulsion) technique using hydroxylpropyl methylcellulose (HPMC) and Ethylcellulose (EC) as the rate controlling polymers. The surface morphology of prepared microspheres was characterized by scanning electron microscopy. The microspheres were found to be spherical in shape and porous in nature. Particle size analysis, drug entrapment efficiency, surface morphology, buoyancy percentage and release studies were performed. Results showed that the Tapped density, carr’s compressibility index, Angle of repose, Percentage yield, In vitro buoyancy, % entrapment efficiency of carvedilol loaded floating microspheres was found to be 0.42±0.012, 12.5±1.895, 23.5±1.856, 80.2% ,79.0% ,85.81±1.40 . The developed floating microsphere of carvedilol released the drug for 24 hrs. It was concluded that developed floating microspheres of carvedilol offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.
     
Type of Study: Research | Subject: Pharmaceutics

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2019 All Rights Reserved | Pharmaceutical and Biomedical Research

Designed & Developed by : Yektaweb