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Aluminum recognized as a public health concern because of its potential toxic effects on human health. Therefore, the present experiment was undertaken to determine the effectiveness of curcumin (CUR) in reducing the toxicity of aluminum chloride (AlCl₃). In this experimental study, forty male Wistar rats were allocated to five groups (N = 8), viz. no treatment (control), solvent (DMSO or distilled water), CUR (10 mg/kg B.W.), AlCl₃ (10 mg/kg B.W.), and CUR+AlCl₃ (each with 10 mg/kg B.W.). Treatments were performed by intra-peritoneal injections for 28 days.  On the final day, animals were sacrificed, and liver function markers in blood plasma, hepatic antioxidants, and lipid peroxidation index in liver homogenate were estimated. AlCl₃ treatment resulted in a significant increase in plasma AST, ALT, ALP and LDH activities with decreased total protein compared to control. AlCl₃ significantly reduced superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels but increased malondialdehyde (MDA) level in the liver compared to control. AlCl₃ also caused various histopathological changes in the livers of rats. Curcumin could normalize nearly all these parameters. CUR improved levels of changes in different parameters when was combined with AlCl₃. It is concluded that CUR has beneficial influences being able to antagonize AlCl₃ toxicity.

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Background: Globally, permethrin is used as an insecticide for pest control in indoor environments and in agriculture to enhance food production by eradicating undesirable insects and controlling disease vectors. 
Objective: The present study investigated the protective effects of Taraxacum officinale (dandelion) on permethrin-induced liver injury in mice. 
Methods: Adult mice were divided into four groups. The first group was the negative control group, whereas the second group was the positive control group that received dandelion through the diet at 2% (corresponding to a dose of 5 g/kg bw). The third group received permethrin (96 mg/kg bw) by gavage, whereas the fourth group received permethrin and a diet enriched with dandelion (cotreatment). All mice were sacrificed after 14 days of treatment.
Results: Biomarkers of liver toxicity (AST, ALT, ALP, and LDH activities and bilirubin level) increased following permethrin treatment. Permethrin induced oxidative stress, which was indicated by an increase in MDA and GSH levels as well as GPx activity and a decrease in SOD activity. Permethrin treatment caused histological alterations in the liver, whereas co-treatment with dandelion reduced liver injury. Our results revealed that alterations of biochemical parameters and liver histological profile in mice following permethrin exposure were reversed towards normalization by the treatment with dandelion roots extract. 
Conclusion: The protective effect of this plant might be due to its antioxidant capacity.

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