Volume 1, Issue 2 (2015)                   Pharm Biomed Res 2015, 1(2): 20-29 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shokri G, Fathi H, Jafari Sabet M, Nasri Nasrabadi N, Ataee R. Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats. Pharm Biomed Res. 2015; 1 (2) :20-29
URL: http://pbr.mazums.ac.ir/article-1-43-en.html
1- Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
2- Department of Biology, Payame Noor University, Tehran,Iran
3- Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (5621 Views)

Today diabetes is one of the most common diseases in the world that affects half of the world population. The use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectiveness. So, this study was conducted to evaluate the effect of cinnamon and green tea extract, individually and in combination, on blood glucose and weight loss in diabetic mice with Streptozotocin (STZ). The experiment was performed on 50 Wistar rats.  A total of 50 rats were divided into 10 groups of 5 and STZ was injected at the dose of 40 mg/kg/day for 5 days intraperitoneally. After diabetes induction, three groups received, 50, 100 and 200 mg doses of green tea extract,  three groups received 50, 100 and 200 mg doses of cinnamon extract  and three final groups received 50, 100 and 200 mg doses of  cinnamon  and green tea in combination by gavages daily for 6 weeks. After each period of treatments, blood glucose and the weight of animals were determined. At the end of the sixth week, blood glucose and weight loss were improved in diabetic rats in a dose-dependent manner and the dose of 200 mg/kg extract cinnamon with green tea had the most appropriate synergic effect.

Full-Text [PDF 846 kb]   (2972 Downloads)    
Type of Study: Original Research | Subject: Natural products

Add your comments about this article : Your username or Email:

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Pharmaceutical and Biomedical Research

Designed & Developed by : Yektaweb