Volume 6, Issue 4 (2020)                   Pharm Biomed Res 2020, 6(4): 261-268 | Back to browse issues page


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Arjmand A, Abedi B, Hosseini S A. The Effect of Resistance Training on Malondialdehyde and Protein Carbonyl Concentration in the Heart Tissue of Rats Exposed to Stanozolol. Pharm Biomed Res. 2020; 6 (4) :261-268
URL: http://pbr.mazums.ac.ir/article-1-321-en.html
1- Department of Physical Education and Sport Sciences, Faculty of Human Science, Mahallat Branch, Islamic Azad University, Mahallat, Iran.
2- Department of Sport Physiology, Faculty of Human Science, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Abstract:   (1171 Views)
Background: Consumption of anabolic steroids causes damage to various tissues, including the heart. 
Objectives: This study aimed to investigate the effect of Resistance Training (RT) on Malondialdehyde (MDA) and Protein Carbonyl (PC) in the heart tissue of rats exposed to stanozolol (S).
Methods: In this experimental study, 18 rats with the mean age of 8 weeks and weight range of 150 to 200 g were selected and divided into three groups of 6 rats: 1. Sham (normal saline consumption) (Sh), 2. S, and 3. S+RT. For 8 weeks, the S and S+RT groups received 5 mg/kg/d S, and the S+RT group performed 5 RT sessions per week. Measurement of MDA and PC in the heart tissue was performed with the enzyme-linked immunosorbent assay.
Results: Stanozolol had a significant effect on increasing MAD (P=0.001) and PC (P=0.03) in the heart tissue. However, RT led to a decrease in MDA and PC in the heart tissue of rats exposed to S (P=0.001).
Conclusion: It appears that S consumption leads to an increase in MDA and PC levels in the heart tissue, while RT can improve the elevated levels of MDA and PC.
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Type of Study: Original Research | Subject: Chemistry

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