Volume 12, Issue 2 (2026)
Pharm Biomed Res 2026, 12(2): 119-132 |
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amini E, Mirahmadi M, Kaboli Farshchi H, Baniasadi F. Palliative Effects of Date Palm Pollen and Its Green Selenium Nanoparticles on FSH, LH, and Ovarian Histology in PCOS Mouse Model. Pharm Biomed Res 2026; 12 (2) :119-132
URL: http://pbr.mazums.ac.ir/article-1-749-en.html
URL: http://pbr.mazums.ac.ir/article-1-749-en.html
1- Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.
2- Stem Cell and Regenerative Medicine Research Group, Iranian Academic Center for Education, Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran. & Pars Takrokh Pharmaceutical Company, Bu Ali Research Institute, Science and Technology Park, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Quantum Engineering and Photonics Technology Research Center, Sharif University of Technology, Tehran, Iran.
2- Stem Cell and Regenerative Medicine Research Group, Iranian Academic Center for Education, Culture and Research (ACECR), Khorasan Razavi Branch, Mashhad, Iran. & Pars Takrokh Pharmaceutical Company, Bu Ali Research Institute, Science and Technology Park, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Quantum Engineering and Photonics Technology Research Center, Sharif University of Technology, Tehran, Iran.
Abstract: (6 Views)
Background: Polycystic ovarian syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by elevated androgen levels, and infertility resulting from anovulation. Selenium supplementation has been reported to improve follicular quality by enhancing insulin sensitivity, reducing lipid peroxidation, and mitigating inflammatory responses. Additionally, the beneficial effects of selenium and selenium nanoparticles (SeNPs) on insulin resistance in women with PCOS have been well-documented.
Objectives: This study aimed to investigate the effect of green synthesized SeNPs using plant derived compounds, including date palm pollen (DPP) on a mouse model of PCOS.
Methods: Thirty NMRI mice were randomly allocated into 6 groups, including control, PCOS, PCOS+DPP (200 and 20 mg/kg body weight), and PCOS+SeNPs (2 and 0.2 mg/kg body weight). Following 14 days of treatment, serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured and ovarian folliculogenesis were evaluated through histopathological analysis.
Results: The findings indicated that treatment with DPP at a dose of 200 mg/kg resulted in a significant increase in serum FSH levels (P≤0.05) and a significant decrease in LH levels (P≤0.01) as compared with SeNPs (2 and 0.2 mg/kg). In contrast, treatment with SeNPs at dose of 0.2 mg/kg revealed more effective in serum level rather than 2 mg/kg. Histopathological evaluation revealed that the aqueous extract of DPP (200 mg/kg) led to a marked reduction in cystic follicles and an increase in secondary, growing follicles, and corpus luteum rather than treatment with SeNPs (2 and 0.2 mg/kg).
Conclusion: Overall, compared with green synthesized SeNPs, the aqueous extract of DPP appears to exert more pronounced therapeutic effects on PCOS-related ovarian abnormalities, likely due to its bioactive constituents. Nevertheless, additional studies are warranted to elucidate the molecular mechanisms underlying these effects.
Objectives: This study aimed to investigate the effect of green synthesized SeNPs using plant derived compounds, including date palm pollen (DPP) on a mouse model of PCOS.
Methods: Thirty NMRI mice were randomly allocated into 6 groups, including control, PCOS, PCOS+DPP (200 and 20 mg/kg body weight), and PCOS+SeNPs (2 and 0.2 mg/kg body weight). Following 14 days of treatment, serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were measured and ovarian folliculogenesis were evaluated through histopathological analysis.
Results: The findings indicated that treatment with DPP at a dose of 200 mg/kg resulted in a significant increase in serum FSH levels (P≤0.05) and a significant decrease in LH levels (P≤0.01) as compared with SeNPs (2 and 0.2 mg/kg). In contrast, treatment with SeNPs at dose of 0.2 mg/kg revealed more effective in serum level rather than 2 mg/kg. Histopathological evaluation revealed that the aqueous extract of DPP (200 mg/kg) led to a marked reduction in cystic follicles and an increase in secondary, growing follicles, and corpus luteum rather than treatment with SeNPs (2 and 0.2 mg/kg).
Conclusion: Overall, compared with green synthesized SeNPs, the aqueous extract of DPP appears to exert more pronounced therapeutic effects on PCOS-related ovarian abnormalities, likely due to its bioactive constituents. Nevertheless, additional studies are warranted to elucidate the molecular mechanisms underlying these effects.
Keywords: Selenium nanoparticles (SeNPs), Date palm pollen (DPP), Green synthesis, Folliculogenesis, Polycystic ovarian syndrome (PCOS)
Type of Study: Original Research |
Subject:
Cellular and Molecular Biology
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