Volume 11, Issue 3 (2025)
Pharm Biomed Res 2025, 11(3): 0-0 |
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Tahir A, Abdullahi Kobi K, Abba Usman M, Abubakar N, Yunusa S. Pharmacological Assessment of Indigofera hochstetteri: Anti-inflammatory and Analgesic Potential. Pharm Biomed Res 2025; 11 (3)
URL: http://pbr.mazums.ac.ir/article-1-674-en.html
URL: http://pbr.mazums.ac.ir/article-1-674-en.html
1- Department of Pharmacology, Faculty of Basic Medical Sciences, Bauchi State University, Gadau 751105, Nigeria
2- Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto 840001, Nigeria
2- Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Usmanu Danfodiyo University, Sokoto 840001, Nigeria
Abstract: (42 Views)
Background: Inflammation and pain are essential physiological responses that protect the body from harmful stimuli. However, when chronic, they can result to severe health issues and disability. The available treatment options have significant limitations which necessitates the search for safer alternatives. This study evaluated the anti-inflammatory and analgesic potentials of the methanol leaf extract of Indigofera hochstetteri.
Methods: The methanol extract of I. hochstetteri was subjected to phytochemical screening and acute toxicity assessment using Lorke’s method. The anti-inflammatory activity was examined using formalin-induced paw edema, and xylene-induced ear edema, while acetic acid-induced writhing and hot plate tests were employed to assess the analgesic activity.
Results: The phytochemical analysis indicated the existence of flavonoids, glycosides, terpenes, and saponins. Acute toxicity studies indicated a moderate toxicity level with a median lethal dose of 2,154 mg/kg, indicating moderate toxicity. The extract displayed statistically significant (p < 0.05) anti-inflammatory effects in both the formalin and xylene models. Substantial analgesic activity in both the writhing and hot plate tests was also observed. The extract's efficacy was directly proportional to the dose, with larger doses (300 mg/kg and 600 mg/kg) showing similar effectiveness to the standard drugs.
Conclusion: These findings imply that I. hochstetteri has promising potential as a natural alternative for managing inflammation and pain.
Methods: The methanol extract of I. hochstetteri was subjected to phytochemical screening and acute toxicity assessment using Lorke’s method. The anti-inflammatory activity was examined using formalin-induced paw edema, and xylene-induced ear edema, while acetic acid-induced writhing and hot plate tests were employed to assess the analgesic activity.
Results: The phytochemical analysis indicated the existence of flavonoids, glycosides, terpenes, and saponins. Acute toxicity studies indicated a moderate toxicity level with a median lethal dose of 2,154 mg/kg, indicating moderate toxicity. The extract displayed statistically significant (p < 0.05) anti-inflammatory effects in both the formalin and xylene models. Substantial analgesic activity in both the writhing and hot plate tests was also observed. The extract's efficacy was directly proportional to the dose, with larger doses (300 mg/kg and 600 mg/kg) showing similar effectiveness to the standard drugs.
Conclusion: These findings imply that I. hochstetteri has promising potential as a natural alternative for managing inflammation and pain.
Type of Study: Original Research |
Subject:
Ehtnopharmacology
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