Volume 11, Issue 4 (2025)
Pharm Biomed Res 2025, 11(4): 339-346 |
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Ghorbani S, Owliaey H, Aghazadeh-Habashi K, Razavi F, Rostami N, Rafatmagham S, et al . Acute Respiratory Distress Syndrome in Drug and Chemical Poisoning: A Cross-sectional Study. Pharm Biomed Res 2025; 11 (4) :339-346
URL: http://pbr.mazums.ac.ir/article-1-661-en.html
URL: http://pbr.mazums.ac.ir/article-1-661-en.html
Saeed Ghorbani1 
, Hamid Owliaey *2 , Komeil Aghazadeh-Habashi3 , Fatemeh Razavi1 , Navid Rostami4 , Sareh Rafatmagham5 , Hamid Reza Ghasemirad6 , Fatemeh Mahdizadeh Gazoui1 , Mehrdad Kiasi1 , Mohsen Jabbari1 , Khashayar Moravej7 , Rouzina Shabani1
, Hamid Owliaey *2 , Komeil Aghazadeh-Habashi3 , Fatemeh Razavi1 , Navid Rostami4 , Sareh Rafatmagham5 , Hamid Reza Ghasemirad6 , Fatemeh Mahdizadeh Gazoui1 , Mehrdad Kiasi1 , Mohsen Jabbari1 , Khashayar Moravej7 , Rouzina Shabani1
1- Department of Medical Science, Yaz.C., Islamic Azad University, Yazd, Iran.
2- Department of Forensic Medicine & Clinical Toxicology, Yaz.C., Islamic Azad University, Yazd, Iran.
3- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4- School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Department of Internal Medicine, Fasa University of Medical Sciences, Fasa, Iran.
6- Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
7- Faculty of Dentistry, Is.C., Islamic Azad University, Isfahan, Iran.
2- Department of Forensic Medicine & Clinical Toxicology, Yaz.C., Islamic Azad University, Yazd, Iran.
3- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4- School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Department of Internal Medicine, Fasa University of Medical Sciences, Fasa, Iran.
6- Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
7- Faculty of Dentistry, Is.C., Islamic Azad University, Isfahan, Iran.
Abstract: (44 Views)
Background: Poisonings are a major medical emergency, contributing to 15-20% of hospital visits. Acute respiratory distress syndrome (ARDS), defined by acute hypoxemia and non-cardiogenic pulmonary edema, presents significant challenges in diagnosis and management.
Objectives: This study investigates the incidence of ARDS in patients with drug and chemical poisoning hospitalized at Shah Vali Hospital in Yazd City, and Shahid Beheshti Hospital in Taft City, Iran from 2014 to 2023.
Methods: We conducted a descriptive cross-sectional study involving patients with drug and chemical poisoning presenting to the emergency departments of the two hospitals. After obtaining ethical approval, we reviewed medical records of eligible patients. Data were analyzed using SPSS software, version 25, presenting qualitative data as frequencies and percentages, and quantitative data as Mean±SD. The chi-square test assessed statistical significance, with P<0.05 deemed significant.
Results: Our analysis included 61 patients, comprising 77% men and 23% women, with a mean age of 46.1 years and an average hospitalization duration of 9.7 days. The primary cause of poisoning was suicide, accounting for 49.2% of cases, predominantly through oral ingestion (96.7%). Methadone was identified as the most common poisoning agent. Notably, 68.9% of patients had a history of addiction, and 27.9% required dialysis, while sepsis was present in 31.1% of cases. Among patients with ARDS, 21.3% had pre-existing pulmonary conditions. Elevated urea and creatinine levels were observed in 85.2% of cases, and metabolic acidosis was noted in all patients. Seizures occurred in 32.8% of individuals, with an overall mortality rate of 59%. Although no significant differences in mortality were associated with addiction history (P=0.310), a strong correlation was found with the type of poisoning agents (P<0.001).
Conclusion: The study found 59% mortality rate among ARDS patients due to drug and chemical poisoning, emphasizing the need for effective management strategies. A significant proportion of cases were involved with addiction, primarily to methadone, yet no mortality correlation with addiction was observed. The findings underscore the complexities of treating ARDS in the context of poisoning, necessitating a diverse approach to improve patient outcomes.
Objectives: This study investigates the incidence of ARDS in patients with drug and chemical poisoning hospitalized at Shah Vali Hospital in Yazd City, and Shahid Beheshti Hospital in Taft City, Iran from 2014 to 2023.
Methods: We conducted a descriptive cross-sectional study involving patients with drug and chemical poisoning presenting to the emergency departments of the two hospitals. After obtaining ethical approval, we reviewed medical records of eligible patients. Data were analyzed using SPSS software, version 25, presenting qualitative data as frequencies and percentages, and quantitative data as Mean±SD. The chi-square test assessed statistical significance, with P<0.05 deemed significant.
Results: Our analysis included 61 patients, comprising 77% men and 23% women, with a mean age of 46.1 years and an average hospitalization duration of 9.7 days. The primary cause of poisoning was suicide, accounting for 49.2% of cases, predominantly through oral ingestion (96.7%). Methadone was identified as the most common poisoning agent. Notably, 68.9% of patients had a history of addiction, and 27.9% required dialysis, while sepsis was present in 31.1% of cases. Among patients with ARDS, 21.3% had pre-existing pulmonary conditions. Elevated urea and creatinine levels were observed in 85.2% of cases, and metabolic acidosis was noted in all patients. Seizures occurred in 32.8% of individuals, with an overall mortality rate of 59%. Although no significant differences in mortality were associated with addiction history (P=0.310), a strong correlation was found with the type of poisoning agents (P<0.001).
Conclusion: The study found 59% mortality rate among ARDS patients due to drug and chemical poisoning, emphasizing the need for effective management strategies. A significant proportion of cases were involved with addiction, primarily to methadone, yet no mortality correlation with addiction was observed. The findings underscore the complexities of treating ARDS in the context of poisoning, necessitating a diverse approach to improve patient outcomes.
Type of Study: Original Research |
Subject:
Toxicology
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