Volume 11, Issue 1 (2025)
Pharm Biomed Res 2025, 11(1): 41-48 |
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Dawoud A D H, Abdalbagi M. Evaluation of Anti-psoriatic Activity of Aloe sinkatana Extract on Imiquimod Induced Psoriatic-like Dermatitis in Mice. Pharm Biomed Res 2025; 11 (1) :41-48
URL: http://pbr.mazums.ac.ir/article-1-658-en.html
URL: http://pbr.mazums.ac.ir/article-1-658-en.html
1- Department of Drug Formulation, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan. & Department of Pharmaceutics, Faculty of Pharmacy, National Ribat University, Khartoum, Sudan.
2- Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan.
2- Department of Microbiology & Parasitology, Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Khartoum, Sudan.
Abstract: (117 Views)
Background: One of the most significant Sudanese medicinal plants is Aloe sinkatana, which has considerable pharmacological activity and has been historically used to treat psoriasis and other skin conditions.
Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties.
Methods: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20. At P<0.05, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean±SD was used.
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.
Objectives: This study aims to evaluate the A. sinkatana plant’s anti-psoriatic properties.
Methods: The imiquimod (IMQ)-induced psoriasis mice model was used to evaluate the anti-psoriatic effect of the A. sinkatana plant. So, the effects of 0.1% and 0.2% extracts of A. sinkatana extract on five groups of mice were assessed and compared with the conventional medication, i.e. dexamethasone. Differences between treatment groups were evaluated by a one-way analysis of variance, followed by a post hoc Fisher least significant difference test using the SPSS software, version 20. At P<0.05, differences were deemed significant. A minimum of three replicates were used in each duplicate experiment. For all values, Mean±SD was used.
Results: The extracts showed a significant and remarkably strong anti-psoriatic effect since the percentages of psoriasis-like symptoms were reduced in groups treated with 0.2% Aloe extract (A.E), 0.1% A.E, and dexamethasone 86%, 84%, and 68%, respectively. Both extract concentrations improved the psoriatic lesions and decreased the grading of the treated groups’ psoriasis area and severity index (PASI) scale.
Conclusion: Due to the constant research to develop a safe and effective topical preparation for the treatment of psoriasis, the current study provided an enhanced anti-psoriatic treatment, represented by A. sinkatana extract. This herb may be beneficial in the pharmaceutical formulation of new safe and effective medication for treating psoriasis.
Keywords: Aloe sinkatana, Dermatitis, Extracts, Imiquimod (IMQ), Psoriasis area and severity index (PASI), Mice
Type of Study: Original Research |
Subject:
Pharmacology
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