Volume 12, Issue 4 (2026)
Pharm Biomed Res 2026, 12(4): 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ekwujuru E U, Ofoego U C, Ofoego A N. Acute Hypervitaminosis A: Effects on Blood, Liver, Kidney and Stomach. Pharm Biomed Res 2026; 12 (4)
URL: http://pbr.mazums.ac.ir/article-1-653-en.html
URL: http://pbr.mazums.ac.ir/article-1-653-en.html
1- Department of Natural Sciences, Faculty of Vaal University of Technology, South Africa
2- Department of Anatomy, Faculty of Basic Medical SciencesNnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria
3- Imo State University Owerri, Nigeria
2- Department of Anatomy, Faculty of Basic Medical SciencesNnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria
3- Imo State University Owerri, Nigeria
Abstract: (35 Views)
Background: Vitamin A (VA) has lots of physiological functions in humans. However, excessive intake causes a condition known as hypervitaminosis A (HA), leading to arrays of health issues. Methods: This research evaluated the effect of HA on selected blood parameters, liver, kidney and stomach. A total of 12 adult male Wister rats, weighing 180-240g were divided into two groups (1 and 2) of 6 rats. Group 1 served as control and received feed and distilled water only while group 2 (test group) received 14,286 IU/rat/day of VA orally for two weeks in addition to feed and distilled water. At the end of the experiment, blood samples were collected for biochemical and hematological analysis while the organs of interest (liver, kidney and stomach) were harvested and processed for histological evaluation. Data obtained were considered statistically significant at p≤ 0.05. Results: Results showed that HA caused a statistically lowered red blood cell count, hemoglobin, eosinophil, packed cell volume as well as liver enzymes (aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase). There were however significantly higher (p˂ 0.05) platelet count, urea, creatinine and potassium concentrations in VA treated rats when compared to control. Treated group had renal degeneration, dilated liver sinusoids and slightly degenerated hepatocytes. However, the microarchitecture of the stomach appeared normal in both groups. Conclusion: High dose VA ingested within a short period of time (14 days) caused adverse effects on the blood components as well as the histology of the kidney and liver.
Type of Study: Original Research |
Subject:
Toxicology
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
