en داروسازی هسته ای Nuclear Pharmacy پژوهشي Original Research <p>In this study, production, quality control and biodistribution studies of ¹⁶⁶Ho-zoledronate have been presented as a possible <a name="OLE_LINK2">bone marrow ablative agent. </a>Ho-166 chloride was produced by thermal neutron irradiation of natural ¹⁶⁵Ho(NO₃)₃ samples. ¹⁶⁶Ho-zoledronate complex was prepared by adding the desired amount of zoledronate solution (0.2 mL, 150 mg/ml in 1 M NaOH) to appropriate amount of the ¹⁶⁶HoCl₃solution.&nbsp; Radiochemical purity of the complex was monitored by instant thin layer chromatography (ITLC). Stability studies of the complex in the final preparation and in the presence of human serum were performed up to 48 h. The biodistribution of ¹⁶⁶Ho-zoledronate and ¹⁶⁶HoCl₃in wild-type mice was checked up to 72 h. ¹⁶⁶Ho-zoledronate complex was prepared in high radiochemical purity (> 99%, ITLC) and specific activity of 4.4 GBq/mmol. The major accumulation of radiolabelled complex was observed in the bone tissue. These findings suggest ¹⁶⁶Ho-zoledronatehas can be a possible candidate for bone marrow ablation in patients with multiple myeloma.</p> <p></p> Bone marrow ablation, Ho-166, Zoledronate, biodistribution 14 22 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-57-2&slc_lang=en&sid=1 Mirsaeed Nikzad 10031947532846003844 10031947532846003844 No Department of Inorganic Chemistry, University of Mazandaran,Babol-sar, Iran Amir Reza Jalilian 10031947532846003845 10031947532846003845 Yes Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran Simindokht Shirvani-Arani 10031947532846003846 10031947532846003846 No Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran Ali Bahrami Samani 10031947532846003847 10031947532846003847 No Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran Hamid Golchobian 10031947532846003848 10031947532846003848 No Department of Inorganic Chemistry, University of Mazandaran,Babol-sar, Iran