en فارماسیوتیکس Pharmaceutics پژوهشي Original Research <p>In this study the effect of liquisolid technique on the dissolution profile of spironolactone was evaluated. Different formulations of spironolactone liquisolid compacts were prepared using various amounts of non-volatile vehicles (Poly ethylene glycol 400 and glycerin). The ratio of microcrystalline cellulose (as carrier) to silica (as coating powder material) was 20 for all formulations. After preparing tablets by direct compression with constant compression load, the release profiles were evaluated by USP paddle method. Differential scanning calorimeter (DSC) and FTIR were used to evaluate any interaction between spironolactone and other ingredients. The liquisolid tablets exhibited significantly higher dissolution rates in comparison with conventionally direct compressed tablets. Furthermore results showed dissolution rate enhancement of liquisolid tablets by increase in the amounts of non-volatile vehicles. Differential scanning calorimetry showed that, the drug has got solubilized in the liquid vehicle. FT-IR spectroscopy studies of pure spironolactone, liquisolid compacts, glycerin and PEG400 supported solubilization of the drug in the liquid vehicle too. The FT-IR spectra also showed that no interactions have been occurred between spironolactone and other ingredients. In conclusion the liquisolid technique can be a suitable method in order to prepare rapid release tablets of poorly water-soluble drugs such as spironolactone.</p> Spironolactone, liquisolid technique, dissolution rate, PEG 400 59 70 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-24&slc_lang=en&sid=1 Jafar Akbari 10031947532846001117 10031947532846001117 No Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Majid Saeedi 10031947532846001118 10031947532846001118 No Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran Katayoun Morteza-Semnani 10031947532846001119 10031947532846001119 No Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Zaynab Sadeghi Ghadi 10031947532846001120 10031947532846001120 Yes Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Seyed Saeed Hosseini 10031947532846001121 10031947532846001121 No Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran