en داروسازی بالینی Clinical Pharmacy گزارش مورد case report <strong>Background</strong>: Various atypical antipsychotics have been associated with peripheral edema. The exact mechanism of creating edema is not clear yet.&nbsp;<br> <strong>Case Report</strong>: A 55-year-old woman with schizophrenia developed pedal edema after taking risperidone, which resolved after discontinuation. However, her symptoms returned when risperidone was restarted. Switching to aripiprazole resolved her edema, with a reduction in dosage preventing further swelling. No edema-related side effects were observed during a 6-month follow-up period.<br> <strong>Conclusion</strong>: Therefore, it would be recommended that patients, especially those receiving high doses of aripiprazole or risperidone, should be monitored for these side effects. Despite the very low incidence of edema due to the aripiprazole administration, the probable occurrence of this adverse effect should always be considered by psychiatrists, as it may affect patients&rsquo; compliance with the prescription. In our case, the reappearance of edema is strong evidence indicating risperidone and aripiprazole cause the swelling. &nbsp; Edema, Risperidone, Aripiprazole, Schizophrenia 269 274 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1323-1&slc_lang=en&sid=1 Mojtaba Ahmadi mojtaba.ahmadi12@gmail.com 100319475328460010493 0009-0003-9841-1464 No Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran. Seyed Hamzeh Hosseini shhosseini@mazums.ac.ir 100319475328460010494 100319475328460010494 Yes Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran.