en داروسازی بالینی Clinical Pharmacy گزارش مورد case report <div style="text-align: justify;"><strong>Background</strong>: Many drugs, including antipsychotics, cause an adverse effect, such as excessive sweating (hyperhidrosis). Hyperhidrosis occurs by drugs that act on the thermoregulatory centers in the hypothalamus, spinal, and sympathetic ganglia or on the endocrine system.&nbsp;<br> <strong>Case Report</strong>: This study reports two patients who developed hyperhidrosis while taking aripiprazole. A 38-year-old woman who had a diagnosis of obsessive-compulsive disorder and a 17-year-old boy who developed multiple motor tics continued to take aripiprazole even though they had hyperhidrosis. The dosage of aripiprazole was adjusted to reduce diaphoresis.<br> <strong>Conclusion</strong>: Besides the potential risks of dehydration, electrolyte depletion, and hypothermia, hyperhidrosis may be a distressing and embarrassing symptom that, if not addressed properly, can promote noncompliance with the medication. Therefore, it is imperative to create awareness of this unusual potential adverse effect of aripiprazole.</div> Aripiprazole, Hyperhidrosis, Sweating, Adverse drug event 79 82 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1231-1&slc_lang=en&sid=1 Seyed Hamzeh Hosseini hosseinish20@gmail.com 100319475328460010385 100319475328460010385 No Psychosomatic Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Hamed Ghazvini hghazvini1@gmail.com 100319475328460010386 100319475328460010386 No Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Seyedeh Masoumeh Seyedhosseini Tamijani seyedhoseini_sm@yahoo.com 100319475328460010387 100319475328460010387 No Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran. Raheleh Rafaiee rahelerafaie@gmail.com 100319475328460010388 100319475328460010388 Yes Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran.