en داروسازی بالینی Clinical Pharmacy گزارش مورد case report <div style="text-align: justify;"><strong>Background</strong>: There are only rare case reports that revealed the efavirenz (EFV) toxicity.<br> <strong>Case Report</strong>: This study presents an acute intoxication with 12 g of efavirenz in a 16-year-old healthy girl whose main problem was dose-dependent neurotoxicity. No other serious EFV-related side effects were seen. Previous serious side effects of EFV were observed in HIV-infected patients who underwent long-term combination drug therapy.&nbsp;<br> <strong>Conclusion</strong>: Accordingly, in terms of the key clinical messages, serious adverse effects of efavirenz are expected to be observed in long-term use in combination with other antiretroviral drugs.</div> Efavirenz, Intoxication, Neurotoxicity, Human immunodeficiency virus, Toxicology 73 78 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-931-1&slc_lang=en&sid=1 Minoo Moghimi minoomoghimii@gmail.com 100319475328460010382 100319475328460010382 No Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Zahra Nekoukar nazanin.nekoukar@gmail.com 100319475328460010383 100319475328460010383 No Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Navid Khosravi n.khosravi@mazums.ac.ir 100319475328460010384 100319475328460010384 Yes Department of Emergency Medicine, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.