en داروسازی بالینی Clinical Pharmacy پژوهشي Original Research <span style="font-size:14px;"><span style="font-family:Tahoma;"><strong>Background</strong>: Patients with type 2 diabetes (T2D) often have other associated comorbidities, making them susceptible to drug-related problems (DRPs) which can adversely affect their quality of life. Understanding these problems can provide baseline data to allow informed health decisions and effective management of patients.&nbsp;<br> <strong>Objectives</strong>: This study aims to investigate DRPs in T2D patients with hypertension and find the predictors of these problems.&nbsp;<br> <strong>Methods</strong>: This cross-sectional study was conducted for six months in the internal medicine department of a tertiary care hospital in Lebanon. Participants were 135 adult T2D patients with hypertension who were receiving one or more anti-diabetes drugs, and at least one medication for hypertension. Pharmaceutical care network europe classification system was used to classify the DRPs. Data were collected by two clinical pharmacists using a self-report tool.<br> <strong>Results</strong>: Most of patients were female. Most of them (94.1%) had at least one DRP (1.43&plusmn;0.72 per patient). &ldquo;Non-optimal drug treatment effect&rdquo; was the most frequent problem (48.2%). Achieving the HbA1C target reduced the odds of this problem by 66.6%, while the increased serum creatinine level caused a two-fold increase in this problem. The use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers reduced the odds of DRPs by 86.2% and 83.3%, respectively, while lipid-lowering and anti-anginal drug use caused a four-fold increase in DRPs.&nbsp;<br> <strong>Conclusion</strong>: Early identification of DRPs in diabetic patients with hypertension and their associated factors can help improve their management and reduce the associated mortality and morbidity rates.</span></span> Drug-related problems, Adverse drug reactions, Type 2 Diabetes, Hypertension 231 242 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1155-1&slc_lang=en&sid=1 Georges Hatem georges.r.hatem@gmail.com 100319475328460010325 100319475328460010325 Yes Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadat, Lebanon. Aya Awarkeh aya_awarkeh248@hotmail.com 100319475328460010326 100319475328460010326 No Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadat, Lebanon. Lynne H Jaffal Lynnejaffal@hotmail.com 100319475328460010327 100319475328460010327 No Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadat, Lebanon. Dalia Khachman dalia.khachman@outlook.com 100319475328460010328 100319475328460010328 No Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadat, Lebanon. Amal Al-Hajje amalkeh@hotmail.com 100319475328460010329 100319475328460010329 No Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadat, Lebanon. Salam Zein salam.zein@ul.edu.lb 100319475328460010330 100319475328460010330 No Clinical and Epidemiological Research Laboratory, Faculty of Pharmacy, Lebanese University, Hadat, Lebanon.