en سم شناسی Toxicology پژوهشي Original Research <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background</strong>::Cancer is one of the problems facing societies today and despite new advances in chemotherapy and cancer treatment, there are still many cancers that do not respond to today&rsquo;s treatments. Tarragon with the scientific name of Artemisia dracunculus L. has various flavonoid and polyphenolic compounds and many therapeutic effects.&nbsp;<br> <strong>Objectives</strong>: This study aimed to investigate the cytotoxicity of this plant on different categories of cancer cels.<br> <strong>Methodes</strong>: After collecting the shoots of tarragon and extracting them by the maceration method, the weight of the extract with a yield of 22.25% was 12.9 g. After examining the presence of flavonoids and total phenol, the extract&rsquo;s antioxidant activity was examined using DPPH and FRAP methods. Finally, MTT tests on three cancer cell lines, MCF-7, HT-29, and MKN45, were done using different concentrations of tarragon extract (100, 200, 500, and 1000 &mu;g/mL).<br> <strong>Results</strong>: Total flavonoids were detected at 24&plusmn;1.18 mg of quercetin per gram of extract, and total phenols were detected at 59&plusmn;2.21 mg of gallic acid per gram of extract. Examining the inhibitory effect of DPPH compared to vitamin C, it was found that the hydroalcoholic extract of tarragon has a 50% inhibitory effect. According to the standard curve, the amount of iron reduced by tarragon hydroalcoholic extract is equal to 405&plusmn;0.11 &mu;g/ml. The cytotoxic effect of tarragon hydroalcoholic extract on MCF7, MKN45, and HT-29 cell lines was investigated, and their IC50 values were 1065.669, 881.19, and 743.870 &mu;g/mL, respectively. The A. dracunculus L extract inhibits the growth of cancer cells in various cell lines.&nbsp;<br> <strong>Conclusion</strong>: According to antioxidant tests, it can be said that the anti-cancer effects of tarragon are based on its antioxidant power and phenolic and flavonoid compounds.</span></span></span></div> <span style="font-size:11pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span> <div> <div> <div class="msocomtxt" id="_com_1" language="JavaScript" on=""><illegal tag=""></illegal></div> </div> </div> Cytotoxicity, Cancer, Tarragon, Artemisia dracunculus L, Cell line 27 36 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1025-2&slc_lang=en&sid=1 Farzaneh Motafeghi farzaneh.motafeghi@gmail.com 100319475328460010258 100319475328460010258 Yes Medicinal Plants Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Emran Habibi emrapharm@yahoo.com 100319475328460010259 100319475328460010259 No Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Maryam Firozjaei raha_angel_965@yahoo.com 100319475328460010260 100319475328460010260 No Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. Mohammad Eghbali mohammadeghbali1991@gmail.com 100319475328460010261 100319475328460010261 No Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Parham Mortazavi Parham2276@gmail.com 100319475328460010262 100319475328460010262 No Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Amirhossein Salmanmahiny Amirhsmahiny@gmail.com 100319475328460010263 100319475328460010263 No Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Mohammad Shokrzadeh mslamuki@gmail.com 100319475328460010264 100319475328460010264 No Medicinal Plants Research Center, Mazandaran University of Medical Sciences, Sari, Iran.