Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1394
3
1
gregorian
2015
6
1
1
2
online
1
fulltext
en
Evaluation of anti-diabetic effects of hydroalcoholic extract of green tea and cinnamon on streptozotocin-induced diabetic rats
ترکیبات طبیعی
Natural products
پژوهشي
Original Research
<p>Today diabetes is one of the most common diseases in the world that affects half of the world population. The use of medicinal herbs especially green tea and cinnamon has been taken into consideration for relieving the symptoms of diabetes, but there were some different ideas about their effectiveness. So, this study was conducted to evaluate the effect of cinnamon and green tea extract, individually and in combination, on blood glucose and weight loss in diabetic mice with Streptozotocin (STZ). The experiment was performed on 50 Wistar rats. A total of 50 rats were divided into 10 groups of 5 and STZ was injected at the dose of 40 mg/kg/day for 5 days intraperitoneally. After diabetes induction, three groups received, 50, 100 and 200 mg doses of green tea extract, three groups received 50, 100 and 200 mg doses of cinnamon extract and three final groups received 50, 100 and 200 mg doses of cinnamon and green tea in combination by gavages daily for 6 weeks. After each period of treatments, blood glucose and the weight of animals were determined. At the end of the sixth week, blood glucose and weight loss were improved in diabetic rats in a dose-dependent manner and the dose of 200 mg/kg extract cinnamon with green tea had the most appropriate synergic effect.</p>
Cinnamon, green tea, diabetes, streptozotocin
20
29
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-26-12&slc_lang=en&sid=1
Ghasem
Shokri
10031947532846001139
10031947532846001139
No
Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
Hamed
Fathi
10031947532846001140
10031947532846001140
No
Department of Biology, Payame Noor University, Tehran,Iran
Majid
Jafari Sabet
10031947532846001141
10031947532846001141
No
Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran
Nafiseh
Nasri Nasrabadi
10031947532846001142
10031947532846001142
No
Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran
Ramin
Ataee
10031947532846001143
10031947532846001143
Yes
Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran