en ژنتیک Genetics پژوهشي Original Research <strong>Background</strong>: There is an intense search for the Coronavirus Disease 19 (COVID-19) cure, to stem the spread and burden of the disease worldwide. Studies revealed that epigenetic modifications impact the pathogenesis of some COVID-19 cases, which can be used as therapeutic targets.&nbsp;<br> <strong>Objectives</strong>: This review articulated the role of epigenetics in the pathogenesis and management of COVID-19.<br> <strong>Methods</strong>: Relevant articles published between January 2000 and November 2020 were retrieved from reputable academic databases, including PubMed, SpringerLink, Scopus, and Google Scholar.<br> <strong>Results</strong>: Epigenetic modifications in the COVID-19&rsquo;s pathogen, called the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and host&rsquo;s cells may influence susceptibility or resistance to the disease. Notably, abnormal Deoxyribonucleic Acid (DNA) methylation and histone modification involving immune regulatory genes and molecules, such as cytokines and interferon-regulated genes may compromise immune function and enhance the host&rsquo;s susceptibility and disease severity. The hypomethylation of SARS-CoV-2&rsquo;s receptor, called the Angiotensin-Converting Enzyme 2 (ACE2), causing its overexpression, can also enhance SARS-CoV-2&rsquo;s infectivity. Moreover, SARS-CoV-2 can hijack the host&rsquo;s MicroRNA (miRNA) using its miRNA and compromise the immune function, increasing its infectivity. Fortunately, epigenetic changes are reversible; thus, a therapy that targets the epigenetic changes in the affected case may reverse COVID-19.&nbsp;<br> <strong>Conclusion</strong>: Modifications in the SARS-CoV-2 or host epigenome promote the pathogenesis and severity of COVID-19. Epigenetic changes are reversible, so healthcare providers are advised to formulate therapeutic procedures that target the causal mechanisms in the affected individual.<br> <gdiv></gdiv><gdiv></gdiv><gdiv></gdiv> Coronavirus, Epigenome, Interferons, MicroRNAs, SARS-CoV-2 161 170 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-925-1&slc_lang=en&sid=1 Tajudeen Yahaya yahayatajudeen@gmail.com 10031947532846006721 10031947532846006721 Yes Department of Biological Sciences, Federal University Birnin-Kebbi, Birnin-Kebbi, Nigeria. Esther Oladele eoladele@unilag.edu.ng 10031947532846006722 10031947532846006722 No Biology Unit, Distance Learning Institute, University of Lagos, Lagos, Nigeria. Aminu Muhammed aminudanwanu@gmail.com 10031947532846006723 10031947532846006723 No Department of Biological Sciences, Federal University Birnin-Kebbi, Birnin-Kebbi, Nigeria. Abdulhakeem Haruna abdulhakeemjibrin@gmail.com 10031947532846006724 10031947532846006724 No Department of Biological Sciences, Federal University Birnin-Kebbi, Birnin-Kebbi, Nigeria. Usman Liman umarusmanliman2019@gmail.com 10031947532846006725 10031947532846006725 No Department of Biochemistry and Molecular Biology, Federal University Birnin-Kebbi, Nigeria.