en کارآزمایی بالینی دارو Drug Clinical Investigation گزارش مورد case report In this report, we present a 29-year-old man who experienced EM five days after using sildenafil and tramadol. Based on clinical examination and history, the diagnosis of EM was made confirmed via skin biopsy, which found intra-epidermal bulla filled by fibrinous exudate, some mononuclear cells, and a few eosinophils. The spongiotic epidermis showed lichenoid interface dermatitis, eosinophilic spongiosis, and necrolysis, consistent with EM diagnosis. Fluocinolone, 0.025% ointment, was prescribed for the patient, and the lesions healed after two weeks of treatment. Erythema multiforme, Sildenafil, Tramadol 63 66 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-810-3&slc_lang=en&sid=1 Amir Hossein Ghanbarzamani amirh.ghzamani@gmail.com 10031947532846006654 10031947532846006654 Yes Pharmaceutical Research Center, Department of Clinical pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Ebrahim Salehifar Esalehifar52@gmail.com 10031947532846006655 10031947532846006655 No Pharmaceutical Research Center, Department of Clinical pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Kaveh Kazemian dr.kavehkazemian@gmail.com‏ 10031947532846006656 10031947532846006656 No Department of Clinical Pharmacy, Sina Hospital, Tehran University of Medicine, Tehran, Iran.