Pharmaceutical and Biomedical Research
Pharm Biomed Res
Medical Sciences
http://pbr.mazums.ac.ir
1
admin
2423-4486
2423-4494
10.29252/pbr
8888
en
jalali
1399
4
1
gregorian
2020
7
1
6
3
online
1
fulltext
en
Isobolographic Antinociception of Nonsteroidal Anti-inflammatory Drugs in Rodent Formalin Orofacial Pain
فارماکولوژی
Pharmacology
پژوهشي
Original Research
<strong>Background</strong>: Diverse studies suggest that non-steroidal anti-inflammatory drugs (NSAIDs) induce antinociception through the inhibition of cyclooxygenases.<br>
<strong>Objectives</strong>: This study evaluated the effect of NSAIDs in inducing antinociception either alone or in combination in mice formalin orofacial pain.<br>
<strong>Methods</strong>: Male mice were injected intraperitoneally with dexibuprofen, dexketoprofen, diclofenac meloxicam, metamizole and piroxicam. Then from a dose-response curve the ED50 (dose that produce 50% of maximum effect) was obtained from each drug.<br>
<strong>Results</strong>: The administration of NSAIDs produced a dose-dependent antinociception in both phases of the assay with different potency. Then, combinations of the cited NSAIDs were tested and analyzed by isobolographic analysis. The results demonstrate that the nocifensive<br>
response induced when dexketoprofen (DEX), the dextrorotatory enantiomer of the S (+) configuration of ketoprofen, was combined with piroxicam, diclofenac, dexibuprofen, metamizole, and meloxicam, was synergistic, either in Phase I or Phase II of the formalin orofacial mice assay.<br>
<strong>Conclusion</strong>: The data demonstrated that the NSAIDs administered alone or in combination produce antinociception. These effects need to be explained by other mechanisms of action of NSAIDs other than the simple inhibition of COXs. The findings may be relevant for the relief of acute or chronic pain such as migraine, post‐herpetic neuralgia and tooth pain.
Nonsteroidal anti-inflammatory drugs, Orofacial pain, Isobolographic analysis, Synergism
205
212
http://pbr.mazums.ac.ir/browse.php?a_code=A-10-772-1&slc_lang=en&sid=1
Viviana
Noriega
vnoriega@ciq.uchile.cl
10031947532846005846
10031947532846005846
No
Department of Cardiovascular, Clinical Hospital, Universidad de Chile, Santiago, Chile.
Fernando
Sierralta
fsierral@med.uchile.cl
10031947532846005847
10031947532846005847
No
Pharmacology Program, ICBM, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Nicolás
Aranda
nicolasaranda@med.uchile.cl
10031947532846005848
10031947532846005848
No
Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Ramón
Sotomayor-Zárate
10031947532846005849
10031947532846005849
No
Laboratorio de Neuroquímica y Neurofarmacología, Centro de Neurobiología y Fisiopatología Integrativa, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso.
Paula
Poblete
paula.poblete.g@gmail.com
10031947532846005850
10031947532846005850
No
Clínica alemana, Santiago, Chile.
Juan Carlos
Prieto
jprieto@med.uchile.cl
10031947532846005851
10031947532846005851
No
Department of Cardiovascular, Clinical Hospital, Universidad de Chile, Santiago, Chile.
Hugo F
Miranda
hmiranda@med.uchile.cl
10031947532846005852
10031947532846005852
Yes
Department of Neuroscience, Faculty of Medicine, Universidad de Chile, Santiago, Chile.