en اتنوفارماکولوژی Ehtnopharmacology پژوهشي Original Research The present study aimed to evaluate the hypoglycemic and hypolipidemic activities of <em>Aloe vera </em>mucilage in alloxan-induced diabetic rats. Adult male Wistar rats were assigned into 4 groups (6 rats/group), as follows: the first group (C) served as the controls. The second group of rats (AL) received a single subcutaneous dose of alloxan at 120 mg kg^-1bw. These groups received 1 mL of NaCl 9%. The third group (AL+Av) represented diabetic rats treated with 1 mL of mucilage extracted from <em>Aloe vera</em> leaves. The fourth group (C+Av) corresponded to control rats administered with 1 mL of <em>Aloe vera </em>mucilage. NaCl or <em>Aloe vera </em>mucilage were intraparenterally injected to the rats. Diabetic rats exhibited significant hyperglycemia accompanied by glycosuria. We also observed a significant reduction in the liver weight and glycogen content of the specimen. A reduced level of serum insulin was also observed among diabetic rats. However, the levels of serum triglycerides and total cholesterol increased in alloxan-induced diabetic rats. <em>Aloe vera </em>mucilage administration to diabetic rats partially and totally corrected glycaemia and liver glycogen content and serum insulin level, respectively. The rats&rsquo; lipid status has also been improved. Medicinal plants, including <em>Aloe vera, </em>are expected to correct hyperglycemia and hyperlipidemia in diabetic patients to prevent the adverse effects of synthetic drugs. Aloe vera, Diabetes Mellitus, Rats, Liver, Insulin secretion 29 34 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-747-1&slc_lang=en&sid=1 Mediha Sefi essafimediha@gmail.com 10031947532846004016 10031947532846004016 Yes Department of Life Sciences, Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, Fundamental Sciences, Sfax, Tunisia Mariem Chaâbane maryame.ch@yahoo.com 10031947532846004017 10031947532846004017 No Department of Life Sciences, Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, Fundamental Sciences, Sfax, Tunisia Moez Refrafi rafrafi_moez@yahoo.fr 10031947532846004018 10031947532846004018 No Department of Chemistry, Chemistry Laboratory of Natural Substances, Faculty of Sciences, University of Sfax, Fundamental Sciences, Sfax, Tunisia Najiba Zeghal naj¬_zgh@yahoo.fr 10031947532846004019 10031947532846004019 No Department of Life Sciences, Animal Physiology Laboratory, Faculty of Sciences, University of Sfax, Fundamental Sciences, Sfax, Tunisia