en سم شناسی Toxicology پژوهشي Original Research Capparis<em> spinosa L. </em>(caper) is an aromatic plant, commonly used in the Mediterranean diet, possessing numerous antioxidant compounds, such as phenols, rutin, tocopherols, carotenoids, and vitamin C in its leaves. Thus, the present study investigated the effects of Iranian caper leaves extract on oxidative stress caused by CCl₄ in the mice&rsquo;s liver.This study was conducted on 42 male mice in seven groups. The control group, the sham group, the CCl₄ group, the Iranian caper leaves extract 100, 200, and 400 mg/kg + CCl₄groups. Then, Biochemicals, oxidative stress, and hepatic histopathology parameters were evaluated. The co-administration of Iranian caper leaves extract, and CCl₄ significantly decreased the levels of aspartate aminotransferase, alanine aminotransferase, and reactive oxygen species, malondialdehyde (<em>P</em><0.001) and significantly increased the levels of glutathione and catalase in comparison with the group treated with CCl₄ alone (<em>P</em><0.01). Furthermore, Iranian caper leaves extract improved histopathological changes such as the the inflammation and necrosis of hepatocytes. Iranian caper leaves extract has protective effects on hepatotoxicity induced by CCl_4, mainly through suppressing oxidative stress. Iranian caper, Carbon tetrachloride, Oxidative stress, Liver, Mice 8 14 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-709-1&slc_lang=en&sid=1 Heibatullah Kalantari kalantarih@yahoo.com 10031947532846003998 10031947532846003998 No Medicinal Plants Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Anis Alijani Aalijanianis@yahoo.com 10031947532846003999 10031947532846003999 No Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Parvin Kheradmand Dr.kheradmandpar64@yahoo.com 10031947532846004000 10031947532846004000 No Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Maedeh Goodarzian dr_maedehg@yahoo.com 10031947532846004001 10031947532846004001 No Department of Pathology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Leila Zeidooni leilazeidooni@gmail.com 10031947532846004002 10031947532846004002 Yes Toxicology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran