en سم شناسی Toxicology پژوهشي Original Research <em>Gongronema latifolium</em> (GL) has been used traditionally in the management of various ailments. The effects of GL on some haematological and biochemical parameters in fructose-induced hyperglycaemia were studied. Forty rats were randomly assigned to four groups of 10 rats each. Control was received normal rat chow, fructose + <em>G. latifolium</em> group was received 66% D-fructose mixed with 34% of feed daily. Fructose only group was received 66% D-fructose and the fourth group was received <em>G. latifolium</em> only respectively for 30 days. All animals were fed ad libitum and had free access to water. Oral blood glucose tolerance test was determined using 2 g/Kg in all groups of rats and blood samples were obtained by cardiac puncture for haematological and biochemical analyses. The blood glucose level was significantly raised in fructose-fed only group (140.6 &plusmn; 2.9 mg/dl) when compared to GL+fructose group (110.3 &plusmn;5.8 mg/dl) and control (88.1 &plusmn; 3.6 mg/dl). There was observed significant reductions in blood glucose and glucose tolerance following GL supplementation. The lipid profile values were significantly higher in fructose-fed group compared with other groups but these levels were significantly reduced following GL supplementation. The white blood cells (WBC) and platelets count in GL and fructose + GL group were significantly raised when compared with the control group. The red cell parameters were not significantly altered compared to the control group. The results show that the consumption of <em>G. latifolium</em> reduces hyperglycaemia and hyperlipidaemia hence the cardiovascular risk factors observed in diabetes mellitus. Blood parameters, Fructose, Glucose tolerance, Gongronema latifolium, Hyperglycaemia, Lipid profile 25 31 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-587-1&slc_lang=en&sid=1 Idara Asuquo Okon idyastuk@yahoo.com 10031947532846004037 10031947532846004037 No Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria Usenobong Friday ufot usen_mboso@yahoo.com 10031947532846004038 10031947532846004038 Yes Department of Biological Sciences, Faculty of Natural and Applied sciences, Akwa Ibom State University, Ikot Akpaden, Mkpat Enin L.G.A., Akwa Ibom State, Nigeria Ufuoma Gabriel Onoyeraye ufos234@gmail.com 10031947532846004039 10031947532846004039 No Department of Physiology, College of Medicine, University of Uyo, Uyo, Akwa Ibom State, Nigeria Elvis Onukwugha Nwachukwu elvis.nwachukwu16@gmail.com 10031947532846004040 10031947532846004040 No Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria Daniel Udofia Owu danielowu@unical.edu.ng 10031947532846004041 10031947532846004041 No Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria