en داروسازی بالینی Clinical Pharmacy پژوهشي Original Research Precocious puberty can cause several adverse effects on final growth and social behavior in girls. Recent studies showed that low serum level of vitamin D might be associated with precocious puberty. The aim of this research was to investigate the association between serum vitamin D level and central precocious puberty in girls. Girls with central precocious puberty under the age of eight were enrolled in the study. Subjects with brain tumor, inherent adrenal hyperplasia, or thyroid dysfunction were excluded from the study. Age, weight, height, serum level of vitamin D, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, free thyroxin (FT₄), bone age, thyroid-stimulating hormone (TSH), and Tanner stages were determined for all the subjects. Healthy girls with no precocious puberty were considered as the control group. Finally, 58 girls (28 with central precocious puberty and 30 healthy) were included in the study. The average levels of serum vitamin D were 12.9 &plusmn; 7.8 ng/mL and 15.2&plusmn;5.9 ng/mL in the case and control groups, respectively (<em>P</em> = 0.02). We found that 37% of girls with precocious puberty were in Tanner stage 2 and 63% in stage 3. The serum vitamin D level had considerable relationship with chronological-bone age difference (<em>P</em> < 0.01). Vitamin D deficiency was more common in girls with central precocious puberty than those with normal sexual maturation. Insufficiency and deficiency of vitamin D were more common in girls who were evaluated in this study in comparison with other studies. Vitamin D, precocious puberty, bone age 15 19 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-67-3&slc_lang=en&sid=1 Mohammadreza Rafati محمدرضا رافتی rafati293@yahoo.com 10031947532846003719 10031947532846003719 No Department of Clinical Pharmacy,Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran گروه داروسازی بالینی، دانشکده داروسازی ساری Daniel Zamanfar دانیل زمانفر danielzamanfar@yahoo.com 10031947532846003720 10031947532846003720 Yes Department of Pediatrics, Diabetes Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran گروه اطفال، دانشکده پزشکی Seyedeh-Nesa Rezaeian Shiadeh سیده نساء رضائیان شیاده nesarezaeian@yahoo.com 10031947532846003721 10031947532846003721 No School of Pharmacy, Mashhad University of Medical Sciences, Sari, Iran گروه فارماسیوتیکس دانشکده داروسازی مشهد Fatemeh Faramarzi فاطمه فرامرزی faramarzif1984@gmail.com 10031947532846003722 10031947532846003722 No Department of Clinical Pharmacy, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran گروه داروسازی بالینی، دانشکده داروسازی دانشگاه ایران Mohsen Aarabi محسن اعرابی mohsen_aarabi@yahoo.com 10031947532846003723 10031947532846003723 No Department of Social Medicine, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran گروه پزشکی اجتماعی، دانشکده پزشکی Hamid Rayati Damavandi حمید رعیتی amir11aina@yahoo.com 10031947532846003724 10031947532846003724 No General Practitioner, Astaneh Square, Babol, Iran پزشک عمومی