en فارماسیوتیکس Pharmaceutics پژوهشي Original Research <p>This study quantitatively estimated heavy metals as cadmium, lead, chromium and nickel (Cd, Pb, Cr and Ni) using flame atomic absorption spectrometry (FAAS) in ten lipstick products sold by local markets in Sari, Mazandaran State, Iran. All the samples were digested in HNO₃ and HClO₄and then evaluated for heavy metal contents. All the concentrations are mean value of triplicate experiments for each sample. Analysis of variance (ANOVA) and Tukey post-hoc tests were used to determine significant variations in heavy metal contents and p < 0.05 was considered as significant. The determined range of cadmium, lead, chromium and nickel were 0.01-0.05&nbsp; 𝜇g /g, 0.18-0.80&nbsp; 𝜇g/g, 0.06-0.75 𝜇g/g, and 0.00-0.34 𝜇g/g, respectively. These results showed that nickel and cadmium contents were less than WHO and US FDA safe limit, while for chromium only one samples (No. 5) showed higher concentration than safe limit. The content of lead in all samples were lower than safe limit unless sample 6 which showed high level of lead.</p> Cadmium, Lead, Chromium, Nickel, Lipstick 31 37 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-32-6&slc_lang=en&sid=1 Hamed Naalbandi 10031947532846001185 10031947532846001185 No Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Majid Saeedi 10031947532846001186 10031947532846001186 Yes Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran Omid Moharrami Moghanlou 10031947532846001187 10031947532846001187 No Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Jafar Akbari 10031947532846001188 10031947532846001188 No Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Katayoun Morteza-Semnani 10031947532846001189 10031947532846001189 No Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran Raouf Alizadeh 10031947532846001190 10031947532846001190 No Central Lab., Vice Chancellor of Food and Drug, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Hossein Esfahani-Zadeh 10031947532846001191 10031947532846001191 No Central Lab., Vice Chancellor of Food and Drug, Mazandaran University of Medical Sciences, Sari, Iran Mahgol Tajbakhsh 10031947532846001192 10031947532846001192 No Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran