TY - JOUR JF - mazums-pbr JO - Pharm Biomed Res VL - 7 IS - 4 PY - 2021 Y1 - 2021/10/01 TI - Evaluation of the Antioxidant Potential of Aqueous Extracts of Moringa oleifera Leaf and Cocos nucifera Husk: A Comparative Analysis TT - N2 - Background: Oxidative Stress (OS) can result in several diseases, such as cancer or neurodegenerative illnesses. Plant antioxidants can supplement the body’s antioxidant system, thereby reducing cell oxidation resulting from OS. Objectives: In this research, the antioxidant potential of aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera was evaluated and compared. Methods: Total Phenolic Contents (TPCs), iron-chelating ability, Ferric Reducing Antioxidant Power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging antioxidant activity of aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera are determined spectrophotometrically at varying concentrations (25, 50, 75, 100, 125µg/mL) and 1-sample t test statistical analysis was done using GraphPad Prism. The statistical significance was set at P<0.05. Results: The aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera possess antioxidant activities at all tested concentrations. Significant increases were observed in TPCs, iron-chelating ability, and FRAP of aqueous leaf extract of Moringa oleifera compared with aqueous husk extracts of Cocos nucifera at the same concentration. In contrast, a significant decrease in DPPH scavenging activities was observed. Conclusion: Both aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera are potent antioxidant agents and could be useful in supplementing the endogenous antioxidant system. Albeit, the aqueous leaf extract of Moringa oleifera is a more powerful antioxidant agent. SP - 289 EP - 296 AU - Folasade Ehigie, Adeola AU - Amos Akinyemi, Olalekan AU - Eunice Ayoade, Titilayo AU - Funke Ogundola, Adijat AU - Faith Oyelere, Sunday AU - P. Olabinri, Folasade AD - Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. KW - Ferric Reducing Antioxidant Power (FRAP) KW - 2 KW - 2-Diphenyl-1-picrylhydrazyl (DPPH) KW - Total phenolic contents KW - Iron-chelating ability KW - Antioxidants UR - http://pbr.mazums.ac.ir/article-1-346-en.html DO - 10.18502/pbr.v7i4.9378 ER -