Pharmaceutical and Biomedical Research- Journal News
Cardiac Issues After COVID Infection and Vaccination: New Data

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New data from two different sources on cardiac complications linked to COVID-19 have shown that such issues are low overall, but are higher after infection than after vaccination.

The new information comes from the Centers for Disease Control and Prevention's (CDC's) National Patient-Centered Clinical Research Network (PCORnet), and from a separate large international clinical study published online in Circulation on April 11.

CDC Data

The CDC study analyzed electronic health record data from 40 US healthcare systems from January 1, 2021, to January 31, 2022, on more than 15 million people aged 5 years or older.

It reports a rate of myocarditis or pericarditis after mRNA COVID-19 vaccination of 0-35.9 per 100,000 for males and 0-10.9 per 100,000 for females across different age groups and vaccine cohorts.

Rates of myocarditis or pericarditis after SARS-CoV-2 infection ranged from 12.6-114 per 100,000 for males and 5.4-61.7 per 100,000 for females across different age groups.  

Even among males aged 12-17 years, the group with the highest incidence of cardiac complications after receipt of a second mRNA COVID-19 vaccine dose, the risk was 1.8-5.6 times higher after SARS-CoV-2 infection than after vaccination, the CDC report notes.

"These findings provide important context for balancing risks and benefits of mRNA COVID-19 vaccination among eligible persons ≥ 5 years," the report states. They also "support the continued use of recommended mRNA vaccines among all eligible persons aged ≥ 5 years," it concludes.

International Study

The international study focused on prevalence, clinical characteristics, and outcomes of clinically manifest acute myocarditis in patients with COVID-19 infection.

The study showed a rate of acute myocarditis of 2.4 per 1000 patients hospitalized with COVID-19.

"A small study previously indicated acute myocarditis is a rare occurrence in people infected with COVID-19. Our analysis of international data offers better insight to the occurrence of acute myocarditis during COVID-19 hospitalization, particularly before the COVID-19 vaccines were widely available," coauthor, Enrico Ammirati, MD, PhD, Niguarda Hospital, Milan, Italy, commented.

"This analysis indicates that, although rare, hospitalized patients with acute myocarditis associated with COVID-19 infection have a much greater need for intensive care unit admission, in up to 70.5% of the cases, despite the average age of the individuals in the study being much younger than expected at 38 years old," added coauthor Marco Metra, MD, University of Brescia, Italy. 
Cite this: Cardiac Issues After COVID Infection and Vaccination: New Data - Medscape - Apr 13, 2022.

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