Volume 7, Issue 4 (2021)
Pharm Biomed Res 2021, 7(4): 289-296 |
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Adeola Folasade Ehigie1 
, Olalekan Amos Akinyemi2 
, Titilayo Eunice Ayoade3 , Adijat Funke Ogundola4 , Sunday Faith Oyelere * 1, Folasade P. Olabinri1
, Olalekan Amos Akinyemi2 , Titilayo Eunice Ayoade3 , Adijat Funke Ogundola4 , Sunday Faith Oyelere * 1, Folasade P. Olabinri1
1- Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
2- Department of Chemistry, Federal University of Sao Carlos, Sao Paulo, Brazil.
3- Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
4- Department of Pure and Applied Biology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
2- Department of Chemistry, Federal University of Sao Carlos, Sao Paulo, Brazil.
3- Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
4- Department of Pure and Applied Biology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Abstract: (1280 Views)
Background: Oxidative Stress (OS) can result in several diseases, such as cancer or neurodegenerative illnesses. Plant antioxidants can supplement the body’s antioxidant system, thereby reducing cell oxidation resulting from OS.
Objectives: In this research, the antioxidant potential of aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera was evaluated and compared.
Methods: Total Phenolic Contents (TPCs), iron-chelating ability, Ferric Reducing Antioxidant Power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging antioxidant activity of aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera are determined spectrophotometrically at varying concentrations (25, 50, 75, 100, 125µg/mL) and 1-sample t test statistical analysis was done using GraphPad Prism. The statistical significance was set at P<0.05.
Results: The aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera possess antioxidant activities at all tested concentrations. Significant increases were observed in TPCs, iron-chelating ability, and FRAP of aqueous leaf extract of Moringa oleifera compared with aqueous husk extracts of Cocos nucifera at the same concentration. In contrast, a significant decrease in DPPH scavenging activities was observed.
Conclusion: Both aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera are potent antioxidant agents and could be useful in supplementing the endogenous antioxidant system. Albeit, the aqueous leaf extract of Moringa oleifera is a more powerful antioxidant agent.
Objectives: In this research, the antioxidant potential of aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera was evaluated and compared.
Methods: Total Phenolic Contents (TPCs), iron-chelating ability, Ferric Reducing Antioxidant Power (FRAP), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging antioxidant activity of aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera are determined spectrophotometrically at varying concentrations (25, 50, 75, 100, 125µg/mL) and 1-sample t test statistical analysis was done using GraphPad Prism. The statistical significance was set at P<0.05.
Results: The aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera possess antioxidant activities at all tested concentrations. Significant increases were observed in TPCs, iron-chelating ability, and FRAP of aqueous leaf extract of Moringa oleifera compared with aqueous husk extracts of Cocos nucifera at the same concentration. In contrast, a significant decrease in DPPH scavenging activities was observed.
Conclusion: Both aqueous husk extract of Cocos nucifera and aqueous leaf extract of Moringa oleifera are potent antioxidant agents and could be useful in supplementing the endogenous antioxidant system. Albeit, the aqueous leaf extract of Moringa oleifera is a more powerful antioxidant agent.
Keywords: Ferric Reducing Antioxidant Power (FRAP), 2, 2-Diphenyl-1-picrylhydrazyl (DPPH), Total phenolic contents, Iron-chelating ability, Antioxidants
Type of Study: Original Research |
Subject:
Phyochemistry
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