Volume 6, Issue 1 (2020)
Pharm Biomed Res 2020, 6(1): 53-60 |
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Hosseini S A, Ahmadipour A, Soltani M, Mehdipour M, Mandegary A, Karami-Mohajeri S. Malathion-increased Hepatotoxicity in Diabetic Rats. Pharm Biomed Res 2020; 6 (1) :53-60
URL: http://pbr.mazums.ac.ir/article-1-280-en.html
URL: http://pbr.mazums.ac.ir/article-1-280-en.html
Seyedeh Azam Hosseini1 
, Ahmad Ahmadipour1 , Motahareh Soltani1 , Mohammad Mehdipour1 , Ali Mandegary2 , Somayyeh Karami-Mohajeri * 2
, Ahmad Ahmadipour1 , Motahareh Soltani1 , Mohammad Mehdipour1 , Ali Mandegary2 , Somayyeh Karami-Mohajeri * 2
1- Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
2- Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
2- Department of Pharmacology & Toxicology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Abstract: (1599 Views)
Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus.
Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats.
Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined.
Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe.
Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system.
Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats.
Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg/day orally. After 28 days, fasting blood glucose, Glucose Tolerance Test (GTT), serum aminotransferases, and liver histopathology and antioxidant status were examined.
Results: MT impaired GTT, caused alteration in histopathology of histopathology and antioxidant status of liver in non-diabetic rats. Impairment in GTT did not observe in diabetic rats exposed to MT, but histopathology changes and antioxidant status alteration was more severe.
Conclusion: Repeated sub-lethal dose of MT exacerbated hepatotoxicity in diabetes condition through further impairment in the antioxidant defense system.
Type of Study: Original Research |
Subject:
Toxicology
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