en فارماکولوژی Pharmacology پژوهشي Original Research <strong>Background</strong>: Adverse drug reactions (ADRs) are associated with significant morbidity and mortality. They can negatively impact healthcare resources and cause financial burden on patients.&nbsp;<br> <strong>Objectives</strong>: This study aimed to assess the causality, severity, predictability, and preventability of reported ADRs as per standard scales.<br> <strong>Methods</strong>: A retrospective observational study was conducted in KRIMS, Karwar, from April 2018 to August 2019. All suspected ADRs reported by outpatients and inpatients of various clinical departments were collected and analyzed.<br> <strong>Results</strong>: A total of 159 ADRs were reported in 136 patients. Most patients were adults aged 18-65 years (88.2%). A female preponderance was observed. The skin and central nervous system (CNS) were the predominant organ systems affected (29.6% each). The most common ADRs reported were rashes (14.5%) followed by sedation (8.2%). Antibiotics were the most commonly used drug class (38.5%). Among the individual drugs, &beta;-lactam antibiotics were the most commonly implicated (16%). Most drugs causing ADRs were administered orally (67.5%). The causality of the reported ADRs was probable in 64.2%. Most of the reported ADRs were non-serious (91.2%). A total of 61% of patients experiencing ADRs recovered completely. Of the ADRs, 83.6% were mild, 51.6% were predictable, and 85.5% were not preventable. Most ADRs subsided after withdrawing the offending drug (66.7%).&nbsp;<br> <strong>Conclusion</strong>: Early detection of the causal relationship between drugs and adverse reactions is crucial for their effective management and prevention. Adverse drug reactions (ADRs), Causality, Retrospective, Prevention 261 270 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1397-1&slc_lang=en&sid=1 M R Manasa dr.manasamr@gmail.com 100319475328460011666 100319475328460011666 No Karwar Institute of Medical Sciences Chaitanya Karant chaithu.bargi18@gmail.com 100319475328460011667 100319475328460011667 No Department of Pharmacology, Karwar Institute of Medical Sciences, Karwar, India. BVS Chandrasekhar sekharpharma9@gmail.com 100319475328460011668 100319475328460011668 No Department of Pharmacology, GSL Medical College and General Hospital, Rajahmundry, India. Swetha K drswethak27@gmail.com 100319475328460011669 100319475328460011669 Yes Department of Pharmacology, Yadgiri Institute of Medical Sciences, Yadgiri, India.