en شیمی دارویی Medical Chemistry پژوهشي Original Research <strong>Background</strong>: Heavy metal accumulation has been shown to improve memory impairment, which is the most visible symptom of Alzheimer&rsquo;s disease (AD).&nbsp;<br> <strong>Objectives</strong>: This study was conducted to select and synthesize rhodanine-N-acetic acid (ROD) ligand as an azosulpha drug, as well as its metal complexes containing Fe(III), Mn(III), and Cu(II), to evaluate the iron complex&rsquo;s bioactivity in Swiss Albino rats.<br> <strong>Methods</strong>: A new series of metal complexes were synthesized and characterized using elemental analysis, magnetic susceptibility, spectroscopic, and analytical methods, including Fourier-transform infrared spectroscopy (FT-IR), inductively coupled plasma (ICP), and thermogravimetric analysis (TG). The effects of heavy metal accumulation of the characterized iron complex on rats were investigated through in vivo studies.&nbsp;<br> <strong>Results</strong>: The results indicated that as the iron load in the liver and spleen tissues increased, the iron-binding capacity of the ROD ligand also significantly increased.<br> <strong>Conclusion</strong>: These findings suggest that the activity of ROD metal complexes should be investigated further as a potential prodrug for AD. Rhodanine, Drug, Alzheimer’s disease (AD), Iron, Rats 159 172 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1373-1&slc_lang=en&sid=1 Elem Sabahsan ykaratas@cu.edu.tr 100319475328460011385 0009-0001-7685-9167 No Department of Chemistry, Faculty of Arts and Science, Cukurova University, Adana, Turkey. Emel Yildiz eeyildiz@cu.edu.tr 100319475328460011386 100319475328460011386 Yes Department of Chemistry, Faculty of Arts and Science, Cukurova University, Adana, Turkey. Yusuf Karatas elemseflek@hotmail.com 100319475328460011387 100319475328460011387 No Department of Medical Pharmacology, Faculty of Medicine, Cukurova University, Adana, Turkey.