en اتنوفارماکولوژی Ehtnopharmacology پژوهشي Original Research <strong>Background</strong>: Hypertension is a major public health concern worldwide, contributing to cardiovascular morbidity and mortality. The use of plant-based therapies, such as Euphorbia hirta and Leptadenia hastata, has gained attention for their potential antioxidant, anti-hyperlipidemic, and organ-protective effects.&nbsp;<br> <strong>Objectives</strong>: This study aimed to investigate the phytotherapeutic approach to hypertension using E. hirta and L. hastata extracts in adrenaline-induced hypertensive Wistar rats<br> <strong>Methods</strong>: Utilizing an adrenaline-induced hypertensive rat model, we assessed the effects of E. hirta and L. hastata leaf extracts (50, 100, and 200 mg/kg) on systolic blood pressure, renal function, lipid metabolism, and hematological parameters.<br> <strong>Results</strong>: Antioxidant activity: Increased levels of superoxide dismutase, catalase, and glutathione peroxidase. Lipid profiles: Reduced levels of total cholesterol, triglycerides, and LDL cholesterol. Liver function tests (LFTs): Decreased levels of alanine transaminase and aspartate transaminase. Hematological parameters: Improved red blood cell count, hemoglobin, and packed cell volume (PCV).<br> <strong>Conclusion</strong>: This preclinical investigation provides compelling evidence for the antihypertensive potential of E. hirta and L. hastata leaf extracts, validating their traditional use. These findings underscore the promise of these natural products as adjunctive therapeutics for hypertension management, warranting further clinical investigation. Antihypertensive, Euphorbia hirta, Leptadenia hastata, traditional medicine, Cardiovascular disorders, Phytotherapy, Cardiovascular 139 146 http://pbr.mazums.ac.ir/browse.php?a_code=A-10-1365-1&slc_lang=en&sid=1 Bushirat Oyenike Fagbohun bushirathassan@gmail.com 100319475328460011365 0009-0008-5853-567X No Department of Pharmacy Technician, Ogun State College of Health Science and Technology, Ogun, Nigeria. Ochonung Emmanuel Ogar ochonungemmanuel1@gmail.com 100319475328460011366 0009-0006-1665-9776 No Department of Chemical Engineering, University of Benin, Benin City, Nigeria. Atapia Innocent Messiah messiah.atapia@physci.uniben.edu 100319475328460011367 0009-0001-4655-0935 No Department of Chemical Engineering, University of Benin, Benin City, Nigeria. Hassan Abdulsalam Adewuyi hasselbatch@gmail.com 100319475328460011368 0009-0004-3824-5377 Yes Department of Biochemistry, Federal University of Technology, Minna, Nigeria. Waheed Sakariyau Adio waheedsackson@gmail.com 100319475328460011369 100319475328460011369 No Department of Chemistry and Biochemistry, College of Science, Old Dominion University, Norfolk, United States. Adebimpe Hameedah Oluwatoyin adebimpehameedah@gmail.com 100319475328460011370 100319475328460011370 No Department of Chemistry and Biochemistry, College of Health and Natural Sciences-Keplinger Hall, The University of Tulsa, Oklahoma, United States. Chizoba Victory Obunadike obunadikechizoba1234@gmail.com 100319475328460011371 100319475328460011371 No Department of Industrial Chemistry, College of Pure and Applied Chemistry, Osun State University Osogbo, Osun, Nigeria. Adeleye Adegboyega Edema adeleye07edema@gmail.com 100319475328460011372 100319475328460011372 No Department of Biochemistry, University of Ibadan, Oyo State Nigeria. Samad Hussein husseinsamad02@gmail.com 100319475328460011373 100319475328460011373 No Department of Biochemistry, Federal University of Technology, Minna, Nigeria. Usman Abiola Mohammed abiolau@gmail.com 100319475328460011374 100319475328460011374 No Department of Biological Sciences, AhmanPategi University, Pategi, Nigeria. Tolulope Olukayode Jaiyeola tolulope.jaiyeola@crawforduniversity.edu.ng 100319475328460011375 0009-0003-8208-8404 No Department of Biological Sciences, Crawford University, Ketu Adieowe, Nigeria.